Protein profile

VK055_4313

propanediol utilization PduL family protein

Genome: KpATCC43816

Gene: AIK82858.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GUP7
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Amino acids 210
Annotations 5
Features 8
PDB binders 0
Druggability 0.733

Overview

Basic information about this protein and its source genome.

Accession
VK055_4313
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK82858.1
Status
annotated
Amino acids
210
Structure source
AlphaFold + ColabFold
EC
2.3.1.222
GO
GO:0016747 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). GO:0031469 An organelle found in bacteria consisting of a proteinaceous coat containing metabolic enzymes whose purpose is the sequestration or concentration of metabolites and which has the appearance of a polygonal granule by electron microscopy. GO:0046872 Binding to a metal ion. GO:0051144 The chemical reactions and pathways resulting in the breakdown of propanediol, a sweet, colorless, viscous, hygroscopic liquid with the formula CH3-CHOH-CH2OH.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
96.01

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.733
Structure A0A0H3GUP7
Pocket Pocket 1
P2Rank 0.934
Structure A0A0H3GUP7
Pocket Pocket 1
ColabFold model
FPocket 0.237 · Pocket 1
P2Rank 0.901 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 220 / 4744 genomes with a hit
Normalized 0.046

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 4 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

4
  • GO:0016747 Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
  • GO:0031469 An organelle found in bacteria consisting of a proteinaceous coat containing metabolic enzymes whose purpose is the sequestration or concentration of metabolites and which has the appearance of a polygonal granule by electron microscopy.
  • GO:0046872 Binding to a metal ion.
  • GO:0051144 The chemical reactions and pathways resulting in the breakdown of propanediol, a sweet, colorless, viscous, hygroscopic liquid with the formula CH3-CHOH-CH2OH.

Sequence Features

Domain/signature hits from InterPro and related databases.

8 records
Show feature table
Start End DB Term Name
131 196 Pfam PF06130 Phosphate propanoyltransferase
131 196 InterPro IPR008300 Phosphate propanoyltransferase
23 101 Pfam PF06130 Phosphate propanoyltransferase
23 101 InterPro IPR008300 Phosphate propanoyltransferase
1 204 PANTHER PTHR39453 PHOSPHATE PROPANOYLTRANSFERASE
1 204 InterPro IPR008300 Phosphate propanoyltransferase
1 209 PIRSF PIRSF010130 PduL
1 209 InterPro IPR008300 Phosphate propanoyltransferase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GUP7
AlphaFold — — full sequence — Viewing
ColabFold VK055_4313
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.733

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 22.79 0.883