Protein profile

VK055_4374

L-serine ammonia-lyase

Genome: KpATCC43816

Gene: AIK82917.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GSE0
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Amino acids 455
Annotations 6
Features 12
PDB binders 0
Druggability 0.378

Overview

Basic information about this protein and its source genome.

Accession
VK055_4374
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK82917.1
Status
annotated
Amino acids
455
Structure source
AlphaFold + ColabFold
EC
4.3.1.17
GO
GO:0003941 Catalysis of the reaction: L-serine = pyruvate + NH4+. GO:0051539 Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0006094 The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. GO:0046872 Binding to a metal ion. GO:0009063 The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
73.009
DEG E-value
0.0
Localization
Cytoplasmic
ColabFold pLDDT
95.4

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.378
Structure A0A0H3GSE0
Pocket Pocket 8
P2Rank 0.3
Structure A0A0H3GSE0
Pocket Pocket 1
ColabFold model
FPocket 0.547 · Pocket 5
P2Rank 0.187 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 258 / 4744 genomes with a hit
Normalized 0.054

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 5 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

5
  • GO:0003941 Catalysis of the reaction: L-serine = pyruvate + NH4+.
  • GO:0051539 Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
  • GO:0006094 The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol.
  • GO:0046872 Binding to a metal ion.
  • GO:0009063 The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
3 155 Pfam PF03315 Serine dehydratase beta chain
3 155 InterPro IPR005131 Serine dehydratase beta chain
16 158 SUPERFAMILY SSF143548 Serine metabolism enzymes domain
16 158 InterPro IPR029009 Allosteric substrate binding domain superfamily
2 451 NCBIfam TIGR00720 L-serine ammonia-lyase
2 451 InterPro IPR004644 Iron-sulphur-dependent L-serine dehydratase single chain form
10 158 FunFam G3DSA:3.30.1330.90:FF:000001 L-serine ammonia-lyase 1
184 448 Pfam PF03313 Serine dehydratase alpha chain
184 448 InterPro IPR005130 Serine dehydratase-like, alpha subunit
1 451 PANTHER PTHR30182 L-SERINE DEHYDRATASE
10 159 Gene3D G3DSA:3.30.1330.90 -
10 159 InterPro IPR029009 Allosteric substrate binding domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GSE0
AlphaFold — — full sequence — Viewing
ColabFold VK055_4374
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
8 0.378
1 0.25
13 0.006
2 0.001

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 6.94 0.3
2 5.69 0.228
3 4.24 0.143
4 3.04 0.08
5 2.3 0.048