Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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Sorted by Druggability (descending)

Applied filters EC Number: 4.3.1.17

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EC Number: 4.3.1.17 ×
# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1 VK055_4374 L-serine ammonia-lyase AlphaFold DB model + ColabFold model
4.3.1.17
GO:0003941Catalysis of the reaction: L-serine = pyruvate + NH4+. GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0006094The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. +25 total
Mapped 2 0.378 No Hit 0.0% —
2 VK055_0120 L-serine ammonia-lyase AlphaFold DB model + ColabFold model
4.3.1.17
GO:0003941Catalysis of the reaction: L-serine = pyruvate + NH4+. GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0006094The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. +25 total
Mapped 2 0.365 No Hit 0.0% —
3 VK055_0161 tdcB tdcB AlphaFold DB model + ColabFold model
4.3.1.17
GO:0006520The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups. GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0003941Catalysis of the reaction: L-serine = pyruvate + NH4+. +47 total
No map 0.264 Hit 47.5% 9.61e-15
Page 1 of 1 · 3 total proteins