Protein profile

VK055_4392

NAD dependent epimerase/dehydratase family protein

Genome: KpATCC43816

Gene: AIK82935.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GWU4
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Amino acids 369
Annotations 2
Features 13
PDB binders 0
Druggability 0.864

Overview

Basic information about this protein and its source genome.

Accession
VK055_4392
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK82935.1
Status
annotated
Amino acids
369
Structure source
AlphaFold + ColabFold
GO
GO:0080019 Catalysis of the reaction: a very long-chain fatty acyl-CoA + 2 NADPH + 2 H+ = a very long-chain primary fatty alcohol + 2 NADP+ + CoA. GO:0035336 The chemical reactions and pathways involving long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
24.074
Human E-value
1.77e-10
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
94.23

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.864
Structure A0A0H3GWU4
Pocket Pocket 1
P2Rank 0.96
Structure A0A0H3GWU4
Pocket Pocket 1
ColabFold model
FPocket 0.879 · Pocket 17
P2Rank 0.964 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 51 / 4744 genomes with a hit
Normalized 0.011

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0080019 Catalysis of the reaction: a very long-chain fatty acyl-CoA + 2 NADPH + 2 H+ = a very long-chain primary fatty alcohol + 2 NADP+ + CoA.
  • GO:0035336 The chemical reactions and pathways involving long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
3 152 PANTHER PTHR11011 MALE STERILITY PROTEIN 2-RELATED
3 152 InterPro IPR026055 Fatty acyl-CoA reductase
14 17 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
18 369 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
46 66 Coils Coil Coil
1 2 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
1 17 Phobius SIGNAL_PEPTIDE Signal peptide region
1 350 Gene3D G3DSA:3.40.50.720 -
1 354 SUPERFAMILY SSF51735 NAD(P)-binding Rossmann-fold domains
1 354 InterPro IPR036291 NAD(P)-binding domain superfamily
6 237 Pfam PF07993 Male sterility protein
6 237 InterPro IPR013120 Fatty acyl-coenzyme A reductase, NAD-binding domain
3 13 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GWU4
AlphaFold — — full sequence — Viewing
ColabFold VK055_4392
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.864
5 0.415

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 37.32 0.958
2 3.27 0.114
3 2.95 0.095
4 2.1 0.048
5 1.87 0.037