Protein profile

VK055_4461

hydrogenase maturation peptidase HycI

Genome: KpATCC43816

Gene: hycI AIK83003.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GS61
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Amino acids 145
Annotations 4
Features 22
PDB binders 0
Druggability 0.193

Overview

Basic information about this protein and its source genome.

Accession
VK055_4461
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
hycI AIK83003.1
Status
annotated
Amino acids
145
Structure source
AlphaFold + ColabFold
GO
GO:0008233 Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. GO:0008047 A molecular function regulator that increases a catalytic activity. GO:0004175 Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. GO:0016485 Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
86.62
DEG E-value
2.9000000000000003e-89
Localization
Cytoplasmic
ColabFold pLDDT
87.33

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.193
Structure A0A0H3GS61
Pocket Pocket 12
P2Rank 0.122
Structure A0A0H3GS61
Pocket Pocket 1
ColabFold model
FPocket 0.489 · Pocket 10
P2Rank 0.557 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 113 / 4744 genomes with a hit
Normalized 0.024

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0008233 Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
  • GO:0008047 A molecular function regulator that increases a catalytic activity.
  • GO:0004175 Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.
  • GO:0016485 Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

22 records
Show feature table
Start End DB Term Name
18 129 Pfam PF01750 Hydrogenase maturation protease
18 129 InterPro IPR000671 Peptidase A31 family
1 145 Gene3D G3DSA:3.40.50.1450 -
1 145 InterPro IPR023430 Peptidase HybD-like domain superfamily
1 140 SUPERFAMILY SSF53163 HybD-like
1 140 InterPro IPR023430 Peptidase HybD-like domain superfamily
1 128 CDD cd06067 H2MP_MemB-H2evol
1 128 InterPro IPR004420 Peptidase A31, hydrogenase maturation protease HycI
1 129 NCBIfam TIGR00072 hydrogenase maturation protease
1 129 InterPro IPR000671 Peptidase A31 family
1 137 PANTHER PTHR30302 HYDROGENASE 1 MATURATION PROTEASE
1 137 InterPro IPR000671 Peptidase A31 family
22 39 PRINTS PR00446 Hydrogen uptake protein signature
22 39 InterPro IPR000671 Peptidase A31 family
56 72 PRINTS PR00446 Hydrogen uptake protein signature
56 72 InterPro IPR000671 Peptidase A31 family
4 15 PRINTS PR00446 Hydrogen uptake protein signature
4 15 InterPro IPR000671 Peptidase A31 family
45 55 PRINTS PR00446 Hydrogen uptake protein signature
45 55 InterPro IPR000671 Peptidase A31 family
1 135 NCBIfam TIGR00142 hydrogenase maturation peptidase HycI
1 135 InterPro IPR004420 Peptidase A31, hydrogenase maturation protease HycI

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GS61
AlphaFold — — full sequence — Viewing
ColabFold VK055_4461
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.06 0.046