Protein profile

VK055_4460

toxin SymE, type I toxin-antitoxin system familyprotein

Genome: KpATCC43816

Gene: AIK83004.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3H1X3
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Amino acids 102
Annotations 4
Features 3
PDB binders 0
Druggability 0.104

Overview

Basic information about this protein and its source genome.

Accession
VK055_4460
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK83004.1
Status
annotated
Amino acids
102
Structure source
AlphaFold + ColabFold
GO
GO:0016788 Catalysis of the hydrolysis of any ester bond. GO:0016070 The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. GO:0003723 Binding to an RNA molecule or a portion thereof. GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
76.09

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.104
Structure A0A0H3H1X3
Pocket Pocket 2
P2Rank
Structure A0A0H3H1X3
Pocket No pockets
ColabFold model
FPocket 0.528 · Pocket 3
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 9 / 4744 genomes with a hit
Normalized 0.002

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0016788 Catalysis of the hydrolysis of any ester bond.
  • GO:0016070 The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.
  • GO:0003723 Binding to an RNA molecule or a portion thereof.
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

Sequence Features

Domain/signature hits from InterPro and related databases.

3 records
Show feature table
Start End DB Term Name
17 75 Pfam PF08845 Toxin SymE, type I toxin-antitoxin system
17 75 InterPro IPR014944 Toxin SymE-like
83 102 MobiDBLite mobidb-lite consensus disorder prediction

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3H1X3
AlphaFold — — full sequence — Viewing
ColabFold VK055_4460
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer