Protein profile

VK055_4558

polyketide cyclase / dehydrase and lipid transport family protein

Genome: KpATCC43816

Gene: AIK83096.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GU57
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Amino acids 145
Annotations 3
Features 10
PDB binders 0
Druggability 0.843

Overview

Basic information about this protein and its source genome.

Accession
VK055_4558
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK83096.1
Status
annotated
Amino acids
145
Structure source
AlphaFold + ColabFold
GO
GO:0048039 Binding to ubiquinone, a quinone derivative with a tail of isoprene units. GO:0006744 The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme. GO:0045333 The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration).

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
28.148
Human E-value
7.46e-12
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
90.21
DEG E-value
1.27e-95
Localization
Unknown
ColabFold pLDDT
96.05

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.843
Structure A0A0H3GU57
Pocket Pocket 1
P2Rank 0.784
Structure A0A0H3GU57
Pocket Pocket 1
ColabFold model
FPocket 0.921 · Pocket 1
P2Rank 0.661 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 123 / 4744 genomes with a hit
Normalized 0.026

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0048039 Binding to ubiquinone, a quinone derivative with a tail of isoprene units.
  • GO:0006744 The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme.
  • GO:0045333 The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration).

Sequence Features

Domain/signature hits from InterPro and related databases.

10 records
Show feature table
Start End DB Term Name
1 142 SUPERFAMILY SSF55961 Bet v1-like
4 141 CDD cd07813 COQ10p_like
4 141 InterPro IPR044996 Coenzyme Q-binding protein COQ10-like
2 144 FunFam G3DSA:3.30.530.20:FF:000005 Type II toxin-antitoxin system toxin RatA
10 135 Pfam PF03364 Polyketide cyclase / dehydrase and lipid transport
10 135 InterPro IPR005031 Coenzyme Q-binding protein COQ10, START domain
5 143 PANTHER PTHR12901 SPERM PROTEIN HOMOLOG
5 143 InterPro IPR044996 Coenzyme Q-binding protein COQ10-like
2 143 Gene3D G3DSA:3.30.530.20 -
2 143 InterPro IPR023393 START-like domain superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GU57
AlphaFold — — full sequence — Viewing
ColabFold VK055_4558
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.843

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 17.95 0.811