Protein profile

VK055_4560

smpA

Genome: KpATCC43816

Gene: AIK83098.1 smpA Structure source: ColabFold
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Amino acids 88
Annotations 1
Features 9
PDB binders 0
Druggability 0.708

Overview

Basic information about this protein and its source genome.

Accession
VK055_4560
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK83098.1 smpA
Status
annotated
Amino acids
88
Structure source
ColabFold
GO
GO:0019867 The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
40.506
DEG E-value
1.14e-19
Localization
OuterMembrane
ColabFold pLDDT
77.32

Selected Druggability evidence

ColabFold / curated model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.708
Structure CB_VK055_4560
Pocket Pocket 3
P2Rank
Structure CB_VK055_4560
Pocket No pockets
ColabFold model
FPocket 0.708 · Pocket 3
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 110 / 4744 genomes with a hit
Normalized 0.023

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0019867 The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
9 88 Gene3D G3DSA:3.30.1450.10 -
9 88 InterPro IPR037873 BamE-like
1 87 Hamap MF_00925 Outer membrane protein assembly factor BamE [bamE].
1 87 InterPro IPR026592 Outer membrane protein assembly factor BamE
2 86 PANTHER PTHR37482 OUTER MEMBRANE PROTEIN ASSEMBLY FACTOR BAME
2 86 InterPro IPR026592 Outer membrane protein assembly factor BamE
10 79 Pfam PF04355 SmpA / OmlA family
10 79 InterPro IPR007450 Lipoprotein SmpA/OmlA
9 88 FunFam G3DSA:3.30.1450.10:FF:000001 Outer membrane protein assembly factor BamE

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
ColabFold VK055_4560
ColabFold — — full sequence — Viewing
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
3 0.708