Protein profile

VK055_4581

stationary phase translation inhibitor and ribosome stability factor

Genome: KpATCC43816

Gene: yfiA AIK83119.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GWB1
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Amino acids 102
Annotations 4
Features 13
PDB binders 0
Druggability 0.15

Overview

Basic information about this protein and its source genome.

Accession
VK055_4581
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
yfiA AIK83119.1
Status
annotated
Amino acids
102
Structure source
AlphaFold + ColabFold
GO
GO:0044238 The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism. GO:0022627 The small subunit of a ribosome located in the cytosol. GO:0043024 Binding to a small ribosomal subunit. GO:0045900 Any process that stops, prevents, or reduces the frequency, rate or extent of translational elongation.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
33.721
Localization
Cytoplasmic
ColabFold pLDDT
88.43

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.15
Structure A0A0H3GWB1
Pocket Pocket 2
P2Rank
Structure A0A0H3GWB1
Pocket No pockets
ColabFold model
FPocket 0.053 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 141 / 4744 genomes with a hit
Normalized 0.03

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0044238 The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.
  • GO:0022627 The small subunit of a ribosome located in the cytosol.
  • GO:0043024 Binding to a small ribosomal subunit.
  • GO:0045900 Any process that stops, prevents, or reduces the frequency, rate or extent of translational elongation.

Sequence Features

Domain/signature hits from InterPro and related databases.

13 records
Show feature table
Start End DB Term Name
1 97 FunFam G3DSA:3.30.160.100:FF:000002 Ribosome-associated translation inhibitor RaiA
1 88 NCBIfam TIGR00741 ribosome-associated translation inhibitor RaiA
1 88 InterPro IPR003489 Ribosome hibernation promoting factor/RaiA
1 96 Gene3D G3DSA:3.30.160.100 -
1 96 InterPro IPR036567 Ribosome hibernation promotion factor-like
1 96 SUPERFAMILY SSF69754 Ribosome binding protein Y (YfiA homologue)
82 96 MobiDBLite mobidb-lite consensus disorder prediction
1 82 Pfam PF02482 Sigma 54 modulation protein / S30EA ribosomal protein
1 82 InterPro IPR003489 Ribosome hibernation promoting factor/RaiA
1 82 CDD cd00552 RaiA
82 102 MobiDBLite mobidb-lite consensus disorder prediction
55 82 Coils Coil Coil
1 88 PANTHER PTHR33231 30S RIBOSOMAL PROTEIN

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

No pockets are loaded yet for the displayed AlphaFold model AF_A0A0H3GWB1 structure. Run experimental pocket backfill to show FPocket/P2Rank overlays on this structure.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GWB1
AlphaFold — — full sequence — Viewing
ColabFold VK055_4581
ColabFold — — full sequence — Loaded