Protein profile

VK055_4602

putative S-adenosyl-L-methionine-dependent methyltransferase

Genome: KpATCC43816

Gene: AIK83135.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GRU5
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Amino acids 245
Annotations 7
Features 12
PDB binders 0
Druggability 0.623

Overview

Basic information about this protein and its source genome.

Accession
VK055_4602
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK83135.1
Status
annotated
Amino acids
245
Structure source
AlphaFold + ColabFold
EC
2.1.1.223
GO
GO:0016430 OBSOLETE. Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N6-methyladenine. GO:0008168 Catalysis of the transfer of a methyl group to an acceptor molecule. GO:0003676 Binding to a nucleic acid. GO:0032259 The process in which a methyl group is covalently attached to a molecule. GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0008033 The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
42.857
DEG E-value
1.05e-63
Localization
Unknown
ColabFold pLDDT
89.65

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.623
Structure A0A0H3GRU5
Pocket Pocket 1
P2Rank 0.893
Structure A0A0H3GRU5
Pocket Pocket 1
ColabFold model
FPocket 0.949 · Pocket 1
P2Rank 0.907 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 90 / 4744 genomes with a hit
Normalized 0.019

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 6 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

6
  • GO:0016430 OBSOLETE. Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N6-methyladenine.
  • GO:0008168 Catalysis of the transfer of a methyl group to an acceptor molecule.
  • GO:0003676 Binding to a nucleic acid.
  • GO:0032259 The process in which a methyl group is covalently attached to a molecule.
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0008033 The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
11 245 Hamap MF_01872 tRNA1(Val) (adenine(37)-N6)-methyltransferase [yfiC].
11 245 InterPro IPR022882 tRNA1(Val) (adenine(37)-N6)-methyltransferase
46 129 Pfam PF05175 Methyltransferase small domain
46 129 InterPro IPR007848 Methyltransferase small domain
119 125 ProSitePatterns PS00092 N-6 Adenine-specific DNA methylases signature.
119 125 InterPro IPR002052 DNA methylase, N-6 adenine-specific, conserved site
10 241 Gene3D G3DSA:3.40.50.150 Vaccinia Virus protein VP39
10 241 InterPro IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily
48 127 CDD cd02440 AdoMet_MTases
10 243 PANTHER PTHR47739 TRNA1(VAL) (ADENINE(37)-N6)-METHYLTRANSFERASE
13 176 SUPERFAMILY SSF53335 S-adenosyl-L-methionine-dependent methyltransferases
13 176 InterPro IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GRU5
AlphaFold — — full sequence — Viewing
ColabFold VK055_4602
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.623
14 0.01
13 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 28.91 0.893
2 1.12 0.007
3 1.02 0.005
4 0.92 0.004