Protein profile

VK055_4606

positive regulator of sigma(E), RseC/MucC familyprotein

Genome: KpATCC43816

Gene: AIK83140.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GRU1
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Amino acids 159
Annotations 0
Features 12
PDB binders 0
Druggability 0.698

Overview

Basic information about this protein and its source genome.

Accession
VK055_4606
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK83140.1
Status
annotated
Amino acids
159
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
72.88

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.698
Structure A0A0H3GRU1
Pocket Pocket 4
P2Rank
Structure A0A0H3GRU1
Pocket No pockets
ColabFold model
FPocket 0.426 · Pocket 7
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 82 / 4744 genomes with a hit
Normalized 0.017

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
125 159 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1 73 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1 146 PANTHER PTHR35867 PROTEIN RSEC
1 146 InterPro IPR007359 Positive regulator of sigma(E), RseC/MucC
99 121 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
74 98 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 151 PIRSF PIRSF004923 RseC
1 151 InterPro IPR026268 Protein RseC
104 124 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
99 103 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
73 95 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
8 139 Pfam PF04246 Positive regulator of sigma(E), RseC/MucC

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GRU1
AlphaFold — — full sequence — Viewing
ColabFold VK055_4606
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.698
2 0.544
5 0.304