Protein profile

VK055_4614

4Fe-4S binding domain protein

Genome: KpATCC43816

Gene: AIK83148.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GWU5
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Amino acids 86
Annotations 3
Features 11
PDB binders 0
Druggability 0.454

Overview

Basic information about this protein and its source genome.

Accession
VK055_4614
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK83148.1
Status
annotated
Amino acids
86
Structure source
AlphaFold + ColabFold
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0051539 Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0046872 Binding to a metal ion.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
93.023
DEG E-value
2.43e-57
Localization
Unknown
ColabFold pLDDT
92.43

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.454
Structure A0A0H3GWU5
Pocket Pocket 1
P2Rank 0.091
Structure A0A0H3GWU5
Pocket Pocket 1
ColabFold model
FPocket 0.495 · Pocket 1
P2Rank 0.078 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 212 / 4744 genomes with a hit
Normalized 0.045

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0051539 Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
  • GO:0046872 Binding to a metal ion.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
2 86 Gene3D G3DSA:3.30.70.20 -
1 29 ProSiteProfiles PS51379 4Fe-4S ferredoxin-type iron-sulfur binding domain profile.
1 29 InterPro IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain
8 55 Pfam PF12838 4Fe-4S dicluster domain
8 55 InterPro IPR017896 4Fe-4S ferredoxin-type, iron-sulphur binding domain
1 78 NCBIfam NF033683 YfhL family 4Fe-4S dicluster ferredoxin
2 86 FunFam G3DSA:3.30.70.20:FF:000004 4Fe-4S ferredoxin
5 67 SUPERFAMILY SSF54862 4Fe-4S ferredoxins
9 20 ProSitePatterns PS00198 4Fe-4S ferredoxin-type iron-sulfur binding region signature.
9 20 InterPro IPR017900 4Fe-4S ferredoxin, iron-sulphur binding, conserved site
5 66 PANTHER PTHR24960 PHOTOSYSTEM I IRON-SULFUR CENTER-RELATED

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GWU5
AlphaFold — — full sequence — Viewing
ColabFold VK055_4614
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
5 0.005
3 0.0
4 0.0
6 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 3.29 0.091
2 1.89 0.031