Protein profile

VK055_4616

haloacid dehalogenase-like hydrolase family protein

Genome: KpATCC43816

Gene: AIK83150.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3H1K6
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Amino acids 203
Annotations 3
Features 12
PDB binders 0
Druggability 0.665

Overview

Basic information about this protein and its source genome.

Accession
VK055_4616
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK83150.1
Status
annotated
Amino acids
203
Structure source
AlphaFold + ColabFold
EC
3.1.3.27
GO
GO:0046872 Binding to a metal ion. GO:0008962 Catalysis of the reaction: phosphatidylglycerophosphate + H2O = phosphatidylglycerol + phosphate.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
95.41

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.665
Structure A0A0H3H1K6
Pocket Pocket 4
P2Rank 0.582
Structure A0A0H3H1K6
Pocket Pocket 1
ColabFold model
FPocket 0.705 · Pocket 4
P2Rank 0.627 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 95 / 4744 genomes with a hit
Normalized 0.02

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 2 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

2
  • GO:0046872 Binding to a metal ion.
  • GO:0008962 Catalysis of the reaction: phosphatidylglycerophosphate + H2O = phosphatidylglycerol + phosphate.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
26 46 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
1 203 NCBIfam TIGR01545 phosphatidylglycerophosphatase C
1 203 InterPro IPR006435 HAD-superfamily hydrolase, subfamily IF, YfhB
12 85 Gene3D G3DSA:1.20.1440.100 -
26 48 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
47 203 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1 25 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
2 162 SUPERFAMILY SSF56784 HAD-like
2 162 InterPro IPR036412 HAD-like superfamily
2 201 Gene3D G3DSA:3.40.50.1000 -
2 201 InterPro IPR023214 HAD superfamily
2 184 Pfam PF12710 haloacid dehalogenase-like hydrolase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3H1K6
AlphaFold — — full sequence — Viewing
ColabFold VK055_4616
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.665
1 0.001
2 0.0
3 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 12.82 0.582
2 3.08 0.082
3 1.38 0.014
4 0.92 0.004