Metabolic network

VK055_4639

cysteine desulfurase IscS

Back to protein
Network centrality 0.19167 top 98.8%
Chokepoint Yes

Attractive metabolic target: catalyzes a consuming chokepoint reaction in Thiamine metabolism, more central than 98.8% of genes in this genome.

Pathways

KEGG pathways this gene's reaction(s) belong to.

Thiamine metabolism

Network

Two-hop reaction neighborhood around this protein; pathway boxes use one primary KEGG route per reaction when several mappings exist. Click a pathway box to open its full route map.

Reaction catalyzed by this protein Chokepoint reaction Neighbor reaction Pathway grouping (2+ reactions sharing a route) Connected reaction (arrow shows direction, when known) ⇌ Reversible reaction (double arrow) Cross-pathway connection

Selected reaction

Click a node in the network above, or a row in the table below, to inspect it here.

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EC
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Pathway
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Genes
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Role
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Isoenzymes
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Catalyzed reactions

Every reaction this gene catalyzes, with substrates/products and isoenzyme backup.

RXN-18707

EC - · RXN-18707 · not reversible · 3 isoenzymes

an [L-cysteine desulfurase]-S-sulfanyl-L-cysteine a [TusA]-L-cysteine
→
an [L-cysteine desulfurase]-L-cysteine a [TusA sulfur-carrier protein]-S-sulfanyl-L-cysteine

RXN-18770

EC - · RXN-18770 · not reversible · 3 isoenzymes

an [L-cysteine desulfurase]-S-sulfanyl-L-cysteine a [TtuD protein]-L-cysteine
→
an [L-cysteine desulfurase]-L-cysteine a [TtuD protein]-S-sulfanyl-L-cysteine

RXN-12588

EC 2.8.1.7 · RXN-12588 · not reversible · 3 isoenzymes

L-cysteine an unsulfurated [sulfur carrier]
→
L-alanine a sulfurated [sulfur carrier]

RXN-21560

EC 2.8.1.7 · RXN-21560 · not reversible · 3 isoenzymes

Consuming chokepoint
L-cysteine a [cytidylyl molybdenum cofactor chaperone]-cytidylyl MoO2(OH)-molybdopterin cofactor a reduced two electron carrier
→
L-alanine a [cytidylyl molybdenum cofactor chaperone]-cytidylyl MoO2(S)-molybdenum cofactor H2O an oxidized electron carrier

RXN-21565

EC - · RXN-21565 · not reversible · 3 isoenzymes

an [L-cysteine desulfurase]-S-sulfanyl-L-cysteine a [bis(guanylyl molybdopterin) cofactor chaperone]-L-cysteine
→
an [L-cysteine desulfurase]-L-cysteine a [bis(guanylyl molybdopterin) cofactor chaperone]-S-sulfanyl-L-cysteine

RXN-21566

EC 2.8.1.7 · RXN-21566 · not reversible · 3 isoenzymes

L-cysteine a [bis(guanylyl molybdopterin) cofactor chaperone]-L-cysteine
→
L-alanine a [bis(guanylyl molybdopterin) cofactor chaperone]-S-sulfanyl-L-cysteine

RXN-22697

EC - · RXN-22697 · not reversible · 3 isoenzymes

an [L-cysteine desulfurase]-S-sulfanyl-L-cysteine a [molybdopterin synthase sulfurtransferase]-L-cysteine
→
an [L-cysteine desulfurase]-L-cysteine a [molybdopterin synthase sulfurtransferase]-S-sulfanyl-L-cysteine

RXN-22698

EC 2.8.1.7 · RXN-22698 · not reversible · 3 isoenzymes

L-cysteine a [molybdopterin synthase sulfurtransferase]-L-cysteine
→
L-alanine a [molybdopterin synthase sulfurtransferase]-S-sulfanyl-L-cysteine

RXN-22700

EC 2.8.1.7 · RXN-22700 · not reversible · 3 isoenzymes

L-cysteine a [TusA]-L-cysteine
→
L-alanine a [TusA sulfur-carrier protein]-S-sulfanyl-L-cysteine

RXN-25009

EC - · RXN-25009 · not reversible · 3 isoenzymes

an [L-cysteine desulfurase]-S-sulfanyl-L-cysteine a [4Fe-4S] iron-sulfur cluster linked by 3 L-cysteine residues
→
an [L-cysteine desulfurase]-L-cysteine a [4Fe-5S] iron-sulfur cluster linked by 3 L-cysteine residues

RXN-25010

EC 2.8.1.7 · RXN-25010 · not reversible · 3 isoenzymes

L-cysteine a [4Fe-4S] iron-sulfur cluster linked by 3 L-cysteine residues
→
L-alanine a [4Fe-5S] iron-sulfur cluster linked by 3 L-cysteine residues

RXN-25069

EC 2.8.1.7 · RXN-25069 · not reversible · 3 isoenzymes

L-cysteine a [TtuD protein]-L-cysteine
→
L-alanine a [TtuD protein]-S-sulfanyl-L-cysteine

RXN-9787

EC 2.8.1.7 · RXN-9787 · not reversible · 3 isoenzymes

L-cysteine a [ThiI sulfur-carrier protein]-L-cysteine
→
L-alanine a [ThiI sulfur-carrier protein]-S-sulfanyl-L-cysteine

RXN0-308

EC - · RXN0-308 · not reversible · 3 isoenzymes

L-cysteine an [L-cysteine desulfurase]-L-cysteine
→
L-alanine an [L-cysteine desulfurase]-S-sulfanyl-L-cysteine

RXN0-7437

EC 2.8.1.- · RXN0-7437 · not reversible · 3 isoenzymes

a [SufS L-cysteine desulfurase]-S-sulfanyl-L-cysteine a [SufE sulfur-carrier protein]-L-cysteine
→
a [SufS]-L-cysteine a [SufE sulfur-carrier protein]-S-sulfanyl-L-cysteine

RXN0-7438

EC - · RXN0-7438 · not reversible · 3 isoenzymes

Producing & consuming chokepoint
L-cysteine a [SufS]-L-cysteine
→
a [SufS L-cysteine desulfurase]-S-sulfanyl-L-cysteine L-alanine

RXN0-7439

EC 2.8.1.7 · RXN0-7439 · not reversible · 3 isoenzymes

L-cysteine a [SufE sulfur-carrier protein]-L-cysteine
→
L-alanine a [SufE sulfur-carrier protein]-S-sulfanyl-L-cysteine

RXN8J2-191

EC 2.8.1.7 · RXN8J2-191 · not reversible · 3 isoenzymes

L-cysteine a [tRNA-uridine 2-sulfurtransferase]-L-cysteine
→
L-alanine a [tRNA-uridine 2-sulfurtransferase]-S-sulfanyl-L-cysteine

RXN8J2-192

EC - · RXN8J2-192 · not reversible · 3 isoenzymes

an [L-cysteine desulfurase]-S-sulfanyl-L-cysteine a [tRNA-uridine 2-sulfurtransferase]-L-cysteine
→
an [L-cysteine desulfurase]-L-cysteine a [tRNA-uridine 2-sulfurtransferase]-S-sulfanyl-L-cysteine

Imported from KpATCC43816.sbml · 2026-07-09