KEGG:map00730

Thiamine metabolism

KpATCC43816 - Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

All pathways Protein ranking
Reactions 10
Proteins 10
Metabolites 32
Chokepoints 5

Pathway map

Reaction-to-metabolite flow reconstructed from the imported SBML participants.

Chokepoint reaction Metabolite ⇌ Reversible reaction Currency metabolites hidden
Computing layout…

Connected pathways

Other pathways in this genome that share reactions with this one.

MODEL Unassigned metabolic reactions 21 shared KEGG Glycolysis / Gluconeogenesis 4 shared KEGG Pentose phosphate pathway 3 shared KEGG Galactose metabolism 1 shared KEGG Phenylalanine, tyrosine and tryptophan biosynthesis 1 shared KEGG Vitamin B6 metabolism 1 shared KEGG Terpenoid backbone biosynthesis 1 shared KEGG Glycine, serine and threonine metabolism 1 shared KEGG Ubiquinone and other terpenoid-quinone biosynthesis 1 shared

Reaction table

Catalyzed reactions, mapped genes, and SBML substrates/products.

DXS-RXN

EC 2.2.1.7 · R05636 · DXS-RXN · not reversible

producing
D-glyceraldehyde 3-phosphate pyruvate H+
→
1-deoxy-D-xylulose 5-phosphate CO2
VK055_2182

PYRIMSYN3-RXN

EC 2.7.4.7 · R04509 · PYRIMSYN3-RXN · reversible

4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine ATP
⇌
4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine ADP
VK055_4976

RXN-11319

EC 4.1.99.19 · R10246 · RXN-11319 · not reversible

L-tyrosine S-adenosyl-L-methionine NADPH
→
2-iminoacetate 4-methylphenol 5'-deoxyadenosine L-methionine H+ NADP+
No mapped protein

RXN-12610

EC 2.5.1.3 · R10712 · RXN-12610 · not reversible

2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine H+
→
thiamine phosphate CO2 diphosphate
VK055_3099

RXN-9789

EC 2.7.7.73 · R07459 · RXN-9789 · not reversible

consuming
a [ThiS sulfur-carrier protein] ATP H+
→
a carboxy-adenylated-[ThiS sulfur-carrier protein] diphosphate
VK055_3100

THIAZOLSYN2-RXN

EC 2.8.1.10 · R10247 · THIAZOLSYN2-RXN · not reversible

1-deoxy-D-xylulose 5-phosphate 2-iminoacetate a thiocarboxylated-[ThiS sulfur-carrier protein]
→
2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate a [ThiS sulfur-carrier protein] H2O
No mapped protein

THIAZOLSYN3-RXN

EC 2.7.1.50 · R04448 · THIAZOLSYN3-RXN · not reversible

producing
5-(2-hydroxyethyl)-4-methylthiazole ATP
→
4-methyl-5-(2-phosphooxyethyl)thiazole ADP H+
VK055_4975

THI-P-KIN-RXN

EC 2.7.4.16 · R00617 · THI-P-KIN-RXN · not reversible

consuming
thiamine phosphate ATP
→
thiamine diphosphate ADP
VK055_2185

THI-P-SYN-RXN

EC 2.5.1.3 · R03223 · THI-P-SYN-RXN · not reversible

consuming
4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine 4-methyl-5-(2-phosphooxyethyl)thiazole H+
→
thiamine phosphate diphosphate
VK055_3099