Protein profile

VK055_4672

addiction module antidote protein, HigA family

Genome: KpATCC43816

Gene: AIK83206.1 higA Structure source: ColabFold
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Amino acids 73
Annotations 1
Features 14
PDB binders 0
Druggability 0.027

Overview

Basic information about this protein and its source genome.

Accession
VK055_4672
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK83206.1 higA
Status
annotated
Amino acids
73
Structure source
ColabFold
GO
GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
41.791
DEG E-value
2.47e-11
Localization
Unknown
ColabFold pLDDT
88.47

Selected Druggability evidence

ColabFold / curated model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.027
Structure CB_VK055_4672
Pocket Pocket 3
P2Rank
Structure CB_VK055_4672
Pocket No pockets
ColabFold model
FPocket 0.027 · Pocket 3
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 7 / 4744 genomes with a hit
Normalized 0.001

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records
Show feature table
Start End DB Term Name
2 70 SUPERFAMILY SSF47413 lambda repressor-like DNA-binding domains
2 70 InterPro IPR010982 Lambda repressor-like, DNA-binding domain superfamily
2 68 NCBIfam TIGR02607 HigA family addiction module antitoxin
2 68 InterPro IPR013430 Toxin-antitoxin system, antidote protein, HigA
1 73 Gene3D G3DSA:1.10.260.40 -
1 73 InterPro IPR010982 Lambda repressor-like, DNA-binding domain superfamily
2 69 PANTHER PTHR36924 ANTITOXIN HIGA-1
2 69 InterPro IPR013430 Toxin-antitoxin system, antidote protein, HigA
8 59 Pfam PF01381 Helix-turn-helix
8 59 InterPro IPR001387 Cro/C1-type helix-turn-helix domain
2 60 CDD cd00093 HTH_XRE
2 60 InterPro IPR001387 Cro/C1-type helix-turn-helix domain
13 60 ProSiteProfiles PS50943 Cro/C1-type HTH domain profile.
13 60 InterPro IPR001387 Cro/C1-type helix-turn-helix domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

No pockets are loaded yet for the displayed ColabFold model VK055_4672 structure. Run experimental pocket backfill to show FPocket/P2Rank overlays on this structure.

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Structural evidence

0 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
ColabFold VK055_4672
ColabFold — — full sequence — Viewing