Protein profile

VK055_4740

sulfate ABC transporter, permease protein CysW

Genome: KpATCC43816

Gene: cysW AIK83274.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GVX8
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Amino acids 291
Annotations 5
Features 36
PDB binders 0
Druggability 0.371

Overview

Basic information about this protein and its source genome.

Accession
VK055_4740
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
cysW AIK83274.1
Status
annotated
Amino acids
291
Structure source
AlphaFold + ColabFold
GO
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0008272 OBSOLETE. The directed movement of sulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015419 Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + sulfate(out) = ADP + phosphate + sulfate(in).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
92.096
DEG E-value
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
90.1

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.371
Structure A0A0H3GVX8
Pocket Pocket 17
P2Rank 0.079
Structure A0A0H3GVX8
Pocket Pocket 1
ColabFold model
FPocket 0.967 · Pocket 3
P2Rank 0.061 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 188 / 4744 genomes with a hit
Normalized 0.04

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0008272 OBSOLETE. The directed movement of sulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0015419 Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + sulfate(out) = ADP + phosphate + sulfate(in).

Sequence Features

Domain/signature hits from InterPro and related databases.

36 records
Show feature table
Start End DB Term Name
1 281 PANTHER PTHR30406 SULFATE TRANSPORT SYSTEM PERMEASE PROTEIN
1 281 InterPro IPR005667 Sulphate ABC transporter permease protein 2
20 43 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
202 228 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
125 143 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
63 89 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
269 291 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
21 43 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
2 275 NCBIfam TIGR00969 sulfate ABC transporter permease subunit
2 275 InterPro IPR005667 Sulphate ABC transporter permease protein 2
229 247 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
69 91 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
90 100 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
103 125 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
144 162 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
101 124 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
140 162 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
66 263 CDD cd06261 TM_PBP2
66 263 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
201 223 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 19 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
163 201 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
19 276 NCBIfam TIGR02140 sulfate ABC transporter permease subunit CysW
19 276 InterPro IPR011866 Sulphate ABC transporter, permease protein CysW
81 273 Pfam PF00528 Binding-protein-dependent transport system inner membrane component
81 273 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
66 270 ProSiteProfiles PS50928 ABC transporter integral membrane type-1 domain profile.
66 270 InterPro IPR000515 ABC transporter type 1, transmembrane domain MetI-like
248 268 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
20 277 FunFam G3DSA:1.10.3720.10:FF:000015 Sulfate ABC transporter, permease CysW
246 268 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
16 268 SUPERFAMILY SSF161098 MetI-like
16 268 InterPro IPR035906 MetI-like superfamily
44 62 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
21 276 Gene3D G3DSA:1.10.3720.10 -
21 276 InterPro IPR035906 MetI-like superfamily

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GVX8
AlphaFold — — full sequence — Viewing
ColabFold VK055_4740
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
17 0.371
9 0.213
16 0.053
1 0.004

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 3.02 0.079
2 2.68 0.064
3 1.64 0.022
4 1.08 0.007