Protein profile

VK055_4825

phosphodiesterase, MJ0936 family protein

Genome: KpATCC43816

Gene: AIK83352.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GR68
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Amino acids 183
Annotations 3
Features 14
PDB binders 0
Druggability 0.105

Overview

Basic information about this protein and its source genome.

Accession
VK055_4825
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK83352.1
Status
annotated
Amino acids
183
Structure source
AlphaFold + ColabFold
EC
3.1.4.-
GO
GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0046872 Binding to a metal ion.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
97.41

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.105
Structure A0A0H3GR68
Pocket Pocket 3
P2Rank 0.118
Structure A0A0H3GR68
Pocket Pocket 1
ColabFold model
FPocket 0.19 · Pocket 5
P2Rank 0.176 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 331 / 4744 genomes with a hit
Normalized 0.07

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 2 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

2
  • GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
  • GO:0046872 Binding to a metal ion.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records
Show feature table
Start End DB Term Name
120 144 ProSitePatterns PS01269 Uncharacterized protein family UPF0025 signature.
120 144 InterPro IPR020935 Phosphodiesterase YfcE, conserved site
1 167 NCBIfam TIGR00040 YfcE family phosphodiesterase
1 167 InterPro IPR000979 Phosphodiesterase MJ0936/Vps29
1 164 SUPERFAMILY SSF56300 Metallo-dependent phosphatases
1 164 InterPro IPR029052 Metallo-dependent phosphatase-like
2 161 CDD cd00841 MPP_YfcE
2 161 InterPro IPR041802 YfcE-like, metallophosphatase domain
1 183 Gene3D G3DSA:3.60.21.10 -
1 183 InterPro IPR029052 Metallo-dependent phosphatase-like
3 164 PANTHER PTHR11124 VACUOLAR SORTING PROTEIN VPS29
3 164 InterPro IPR000979 Phosphodiesterase MJ0936/Vps29
1 161 Pfam PF12850 Calcineurin-like phosphoesterase superfamily domain
1 161 InterPro IPR024654 Calcineurin-like phosphoesterase domain, lpxH-type

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GR68
AlphaFold — — full sequence — Viewing
ColabFold VK055_4825
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 3.06 0.101