Protein profile

VK055_4915

cobW/HypB/UreG, nucleotide-binding domain protein

Genome: KpATCC43816

Gene: AIK83441.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GQZ5
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Amino acids 320
Annotations 1
Features 12
PDB binders 0
Druggability 0.964

Overview

Basic information about this protein and its source genome.

Accession
VK055_4915
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK83441.1
Status
annotated
Amino acids
320
Structure source
AlphaFold + ColabFold
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

Target profile

Computed evidence for target prioritization.

Human off-target
hit
Human identity (%)
36.634
Human E-value
2.87e-08
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
34.021
Localization
Cytoplasmic
ColabFold pLDDT
85.75

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.964
Structure A0A0H3GQZ5
Pocket Pocket 2
P2Rank 0.916
Structure A0A0H3GQZ5
Pocket Pocket 1
ColabFold model
FPocket 0.936 · Pocket 1
P2Rank 0.888 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 95 / 4744 genomes with a hit
Normalized 0.02

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
1 188 Gene3D G3DSA:3.40.50.300 -
1 188 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
1 314 PANTHER PTHR13748 COBW-RELATED
235 318 SMART SM00833 CobW_C_3
235 318 InterPro IPR011629 Zinc chaperone CobW-like, C-terminal
2 155 Pfam PF02492 CobW/HypB/UreG, nucleotide-binding domain
2 155 InterPro IPR003495 CobW/HypB/UreG, nucleotide-binding domain
1 161 SUPERFAMILY SSF52540 P-loop containing nucleoside triphosphate hydrolases
1 161 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
2 190 CDD cd03112 CobW-like
237 316 Pfam PF07683 Cobalamin synthesis protein cobW C-terminal domain
237 316 InterPro IPR011629 Zinc chaperone CobW-like, C-terminal

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GQZ5
AlphaFold — — full sequence — Viewing
ColabFold VK055_4915
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.964
21 0.636
1 0.416
23 0.243

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 17.96 0.812
2 17.36 0.801
3 6.72 0.342