Protein profile

VK055_4994

peptidase U32 family protein

Genome: KpATCC43816

Gene: AIK83520.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GQR9
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Amino acids 453
Annotations 4
Features 9
PDB binders 0
Druggability 0.604

Overview

Basic information about this protein and its source genome.

Accession
VK055_4994
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK83520.1
Status
annotated
Amino acids
453
Structure source
AlphaFold + ColabFold
GO
GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008233 Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. GO:0006508 The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0008033 The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
23.282
Localization
Cytoplasmic
ColabFold pLDDT
81.42

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.604
Structure A0A0H3GQR9
Pocket Pocket 1
P2Rank 0.844
Structure A0A0H3GQR9
Pocket Pocket 1
ColabFold model
FPocket 0.576 · Pocket 30
P2Rank 0.916 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 177 / 4744 genomes with a hit
Normalized 0.037

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0008233 Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
  • GO:0006508 The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
  • GO:0008033 The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
75 343 Pfam PF01136 Peptidase family U32
75 343 InterPro IPR001539 Peptidase U32
356 441 Gene3D G3DSA:2.40.30.10 Translation factors
162 180 ProSitePatterns PS01276 Peptidase family U32 signature.
162 180 InterPro IPR001539 Peptidase U32
356 441 FunFam G3DSA:2.40.30.10:FF:000039 U32 family peptidase
1 408 PANTHER PTHR30217 PEPTIDASE U32 FAMILY
359 440 Pfam PF16325 Peptidase family U32 C-terminal domain
359 440 InterPro IPR032525 Peptidase family U32, C-terminal

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GQR9
AlphaFold — — full sequence — Viewing
ColabFold VK055_4994
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.604
2 0.301
27 0.035
3 0.034

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 23.67 0.844
2 5.56 0.22
3 4.8 0.175
4 4.39 0.152
5 1.74 0.026