Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: VK055_5000
Assembly: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene: AIK83526.1
Status: annotated
Amino acids: 412
Structure source: AlphaFold + ColabFold

GO

GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:1990281 A protein complex that is capable of efflux transmembrane transporter activity. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015562 Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Human identity (%): 0.0
Gut microbiome off-target: hit
Essential (DEG): Y
DEG identity (%): 79.036
DEG E-value: 0.0
Localization: CytoplasmicMembrane
ColabFold pLDDT: 86.39

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.162

Structure A0A0H3H0N0

Pocket Pocket 5

P2Rank

Structure A0A0H3H0N0

Pocket No pockets

ColabFold model

FPocket 0.085 · Pocket 13

Core conservation Conserved core gene

Roary core

CoreCruncher core

Gut microbiome 121 / 4744 genomes with a hit

Normalized 0.026

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

6 GO

Gene Ontology (GO)

6

GO:0022857 Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.
GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
GO:1990281 A protein complex that is capable of efflux transmembrane transporter activity.
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO:0015562 Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane.

Sequence Features

Domain/signature hits from InterPro and related databases.

23 records

Show feature table

Start	End	DB	Term	Name
79	298	Gene3D	G3DSA:2.40.30.170	-
120	193	Gene3D	G3DSA:1.10.287.470	Helix hairpin bin
197	297	Pfam	PF13437	HlyD family secretion protein
85	229	Gene3D	G3DSA:2.40.50.100	-
4	393	PANTHER	PTHR30469	MULTIDRUG RESISTANCE PROTEIN MDTA
208	298	FunFam	G3DSA:2.40.30.170:FF:000006	Multidrug resistance protein MdtA
27	412	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
299	391	Gene3D	G3DSA:2.40.420.20	-
9	26	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
61	389	NCBIfam	TIGR01730	efflux RND transporter periplasmic adaptor subunit
61	389	InterPro	IPR006143	RND efflux pump, membrane fusion protein
120	193	FunFam	G3DSA:1.10.287.470:FF:000005	Multidrug resistance protein MdtA
389	412	MobiDBLite	mobidb-lite	consensus disorder prediction
1	8	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
9	26	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
1	410	Hamap	MF_01422	Multidrug resistance protein MdtA [mdtA].
1	410	InterPro	IPR022824	Multidrug resistance protein MdtA
126	153	Coils	Coil	Coil
34	53	MobiDBLite	mobidb-lite	consensus disorder prediction
299	390	FunFam	G3DSA:2.40.420.20:FF:000001	Efflux RND transporter periplasmic adaptor subunit
78	312	SUPERFAMILY	SSF111369	HlyD-like secretion proteins
86	134	Pfam	PF13533	Biotin-lipoyl like
86	134	InterPro	IPR039562	Membrane fusion protein, biotin-lipoyl like domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

No pockets are loaded yet for the displayed AlphaFold model AF_A0A0H3H0N0 structure. Run experimental pocket backfill to show FPocket/P2Rank overlays on this structure.

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold AF_A0A0H3H0N0	AlphaFold	—	—	full sequence	—	Viewing
ColabFold VK055_5000	ColabFold	—	—	full sequence	—	Loaded

VK055_5000