Protein profile

VK055_5013

PAP2 superfamily protein

Genome: KpATCC43816

Gene: AIK83539.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GVV2
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Amino acids 209
Annotations 0
Features 26
PDB binders 0
Druggability 0.897

Overview

Basic information about this protein and its source genome.

Accession
VK055_5013
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK83539.1
Status
annotated
Amino acids
209
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
35.354
Localization
CytoplasmicMembrane
ColabFold pLDDT
90.32

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.897
Structure A0A0H3GVV2
Pocket Pocket 5
P2Rank 0.826
Structure A0A0H3GVV2
Pocket Pocket 1
ColabFold model
FPocket 0.835 · Pocket 9
P2Rank 0.629 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 13 / 4744 genomes with a hit
Normalized 0.003

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

26 records
Show feature table
Start End DB Term Name
40 60 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
128 145 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
128 145 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
157 175 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
6 28 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
91 101 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
71 92 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
146 156 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
5 27 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
123 127 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
102 122 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
61 71 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 5 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
4 151 SUPERFAMILY SSF48317 Acid phosphatase/Vanadium-dependent haloperoxidase
4 151 InterPro IPR036938 Phosphatidic acid phosphatase type 2/haloperoxidase superfamily
42 64 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
63 159 Gene3D G3DSA:1.20.144.10 Phosphatidic acid phosphatase type 2/haloperoxidase
72 90 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
155 177 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
71 146 Pfam PF01569 PAP2 superfamily
71 146 InterPro IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase
176 209 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
16 143 SMART SM00014 acid_phosph_2
16 143 InterPro IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase
29 39 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
102 121 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GVV2
AlphaFold — — full sequence — Viewing
ColabFold VK055_5013
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
5 0.897
11 0.769

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 14.83 0.736
2 3.15 0.107
3 2.5 0.069
4 2.48 0.068
5 1.94 0.04