Protein profile

VK055_5034

UDP-galactopyranose mutase

Genome: KpATCC43816

Gene: AIK83560.1 glf Structure source: Experimental + ColabFold UniProt Q48485
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Amino acids 384
Annotations 5
Features 16
PDB binders 8
Druggability 0.902

Overview

Basic information about this protein and its source genome.

Accession
VK055_5034
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK83560.1 glf
Status
annotated
Amino acids
384
Structure source
Experimental + ColabFold
EC
5.4.99.9
GO
GO:0008767 Catalysis of the reaction: UDP-D-galactopyranose = UDP-D-galacto-1,4-furanose. GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0050660 Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. GO:0009243 The chemical reactions and pathways resulting in the formation of the O side chain of a lipopolysaccharide, which determines the antigenic specificity of the organism. It is made up of about 50 repeating units of a branched tetrasaccharide.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
43.959
DEG E-value
5.96e-102
Localization
Cytoplasmic
ColabFold pLDDT
97.32

Selected Druggability evidence

PDB experimental structure

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.902
Structure 3INR
Pocket Pocket 4
P2Rank 0.988
Structure 3INR
Pocket Pocket 1
ColabFold model
FPocket 0.828 · Pocket 3
P2Rank 0.991 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 21 / 4744 genomes with a hit
Normalized 0.004

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 4 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

4
  • GO:0008767 Catalysis of the reaction: UDP-D-galactopyranose = UDP-D-galacto-1,4-furanose.
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0050660 Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.
  • GO:0009243 The chemical reactions and pathways resulting in the formation of the O side chain of a lipopolysaccharide, which determines the antigenic specificity of the organism. It is made up of about 50 repeating units of a branched tetrasaccharide.

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records
Show feature table
Start End DB Term Name
270 376 Gene3D G3DSA:3.40.50.720 -
1 23 Phobius SIGNAL_PEPTIDE Signal peptide region
248 316 SUPERFAMILY SSF54373 FAD-linked reductases, C-terminal domain
2 373 SUPERFAMILY SSF51971 Nucleotide-binding domain
137 265 Gene3D G3DSA:3.40.50.720 -
1 116 Gene3D G3DSA:3.40.50.720 -
150 349 Pfam PF03275 UDP-galactopyranose mutase
150 349 InterPro IPR015899 UDP-galactopyranose mutase, C-terminal
19 23 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
8 75 Pfam PF13450 NAD(P)-binding Rossmann-like domain
1 6 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
5 365 NCBIfam TIGR00031 UDP-galactopyranose mutase
5 365 InterPro IPR004379 UDP-galactopyranose mutase
7 18 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
24 384 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
2 373 PANTHER PTHR21197 UDP-GALACTOPYRANOSE MUTASE

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

7 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 2BI7
X-ray 2.00 Å A
100.0% 1-384
PDBe RCSB PDBj File
Viewing
PDB 3KYB
X-ray 2.30 Å A,B
100.0% 1-384
PDBe RCSB PDBj File
Loaded
PDB 3INR
X-ray 2.30 Å A,B
99.7% 1-383
PDBe RCSB PDBj File
Loaded
PDB 1WAM
X-ray 2.35 Å A
100.0% 1-384
PDBe RCSB PDBj File
Loaded
PDB 2BI8
X-ray 2.35 Å A
100.0% 1-384
PDBe RCSB PDBj File
Loaded
PDB 3GF4
X-ray 2.45 Å A,B
100.0% 1-384
PDBe RCSB PDBj File
Loaded
PDB 3INT
X-ray 2.51 Å A,B
100.0% 1-384
PDBe RCSB PDBj File
Loaded
ColabFold VK055_5034
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
7 0.416

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 34.91 0.952
2 9.28 0.497
3 1.16 0.009
4 0.66 0.001

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

58 records

Highest-confidence structural evidence: ligands co-crystallized with this exact protein. If the source PDB is loaded in TPW, use Open crystal to inspect it in the structure viewer.

Show only:
Ligand Source crystal MW · LogP · TPSA Lipinski PAINS SMILES
FDA
3INT 2.51 Å Open crystal
787.6 Da LogP -1.75 TPSA 363.3 3 viol. ✓ Clean Cc1cc2c(cc1C)N(C3=C(N2)C(=O)NC(=O)N3)C[C@@H]([C…
GDU
3INR 2.30 Å Open crystal
566.3 Da LogP -4.79 TPSA 297.0 3 viol. ✓ Clean C1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)C…
UPG
3GF4 2.45 Å Open crystal
566.3 Da LogP -4.79 TPSA 297.0 3 viol. ✓ Clean C1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)C…

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.