Protein profile

VK055_5059

HPP family protein

Genome: KpATCC43816

Gene: AIK83585.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3H0H4
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Amino acids 243
Annotations 0
Features 22
PDB binders 0
Druggability 0.221

Overview

Basic information about this protein and its source genome.

Accession
VK055_5059
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK83585.1
Status
annotated
Amino acids
243
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
43.913
DEG E-value
1.6299999999999998e-48
Localization
CytoplasmicMembrane
ColabFold pLDDT
88.15

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.221
Structure A0A0H3H0H4
Pocket Pocket 1
P2Rank 0.045
Structure A0A0H3H0H4
Pocket Pocket 1
ColabFold model
FPocket 0.06 · Pocket 16
P2Rank 0.046 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 20 / 4744 genomes with a hit
Normalized 0.004

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

22 records
Show feature table
Start End DB Term Name
96 118 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
59 76 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
32 54 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
62 181 Pfam PF04982 HPP family
62 181 InterPro IPR007065 HPP
32 53 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
177 243 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
17 182 PANTHER PTHR33741 TRANSMEMBRANE PROTEIN DDB_G0269096-RELATED
132 148 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
83 101 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
154 176 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
126 131 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
150 172 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
107 125 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
102 106 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
77 82 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
215 235 Coils Coil Coil
54 58 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
123 145 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 31 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
149 153 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
59 81 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3H0H4
AlphaFold — — full sequence — Viewing
ColabFold VK055_5059
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.221