Metabolic network

VK055_5062

putative lipoate-protein ligase A

Back to protein
Network centrality 0.02487 top 93.2%
Chokepoint Yes

Attractive metabolic target: catalyzes a producing chokepoint reaction in Lipoic acid metabolism, more central than 93.2% of genes in this genome, no human homolog detected.

Pathways

KEGG pathways this gene's reaction(s) belong to.

Lipoic acid metabolism

Network

Two-hop reaction neighborhood around this protein; pathway boxes use one primary KEGG route per reaction when several mappings exist. Click a pathway box to open its full route map.

Reaction catalyzed by this protein Chokepoint reaction Neighbor reaction Pathway grouping (2+ reactions sharing a route) Connected reaction (arrow shows direction, when known) ⇌ Reversible reaction (double arrow) Cross-pathway connection

Selected reaction

Click a node in the network above, or a row in the table below, to inspect it here.

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EC
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Pathway
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Genes
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Role
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Isoenzymes
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Catalyzed reactions

Every reaction this gene catalyzes, with substrates/products and isoenzyme backup.

RXN-8655

EC - · RXN-8655 · not reversible · 2 isoenzymes

[(R)-lipoyl]adenylate a [lipoyl-carrier protein]-L-lysine
→
a [lipoyl-carrier protein]-N6-[(R)-lipoyl]-L-lysine AMP 2 H+

RXN0-5098

EC 6.3.1.20 · RXN0-5098 · not reversible · 2 isoenzymes

a [lipoyl-carrier protein]-L-lysine octanoate ATP
→
a [lipoyl-carrier protein] N6-octanoyl-L-lysine AMP diphosphate H+

RXN-8654

EC - · RXN-8654 · not reversible · 2 isoenzymes

(R)-lipoate ATP H+
→
[(R)-lipoyl]adenylate diphosphate

RXN0-1141

EC 6.3.1.20 · RXN0-1141 · not reversible · 2 isoenzymes

[glycine cleavage system lipoyl-carrier protein]-L-lysine ATP (R)-lipoate
→
AMP diphosphate a [glycine-cleavage complex H protein] N6-[(R)-lipoyl]-L-lysine H+

RXN-17127

EC 6.3.1.20 · RXN-17127 · not reversible · 2 isoenzymes

a [lipoyl-carrier protein]-L-lysine (R)-lipoate ATP
→
a [lipoyl-carrier protein]-N6-[(R)-lipoyl]-L-lysine AMP diphosphate H+

RXN-13039

EC - · RXN-13039 · not reversible · 2 isoenzymes

[(R)-lipoyl]adenylate [glycine cleavage system lipoyl-carrier protein]-L-lysine
→
a [glycine-cleavage complex H protein] N6-[(R)-lipoyl]-L-lysine AMP 2 H+

RXN-25163

EC 6.3.1.20 · RXN-25163 · not reversible · 2 isoenzymes

an [LbpA protein]-L-lysine octanoate ATP
→
an [LbpA protein] N6-octanoyl-L-lysine AMP diphosphate H+

RXN-25164

EC - · RXN-25164 · not reversible · 2 isoenzymes

an [LbpA protein]-L-lysine (octanoyl)adenylate
→
an [LbpA protein] N6-octanoyl-L-lysine AMP 2 H+

RXN-24036

EC - · RXN-24036 · not reversible · 2 isoenzymes

a [lipoyl-carrier protein]-L-lysine (octanoyl)adenylate
→
a [lipoyl-carrier protein] N6-octanoyl-L-lysine AMP 2 H+

RXN0-7423

EC - · RXN0-7423 · not reversible · 2 isoenzymes

Producing chokepoint
octanoate ATP H+
→
(octanoyl)adenylate diphosphate

Imported from KpATCC43816.sbml · 2026-07-09