Protein profile

VK055_5081

type IV secretory system Conjugative DNA transfer family protein

Genome: KpATCC43816

Gene: AIK83607.1 Structure source: AlphaFold + ColabFold UniProt A4GZH1
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Amino acids 629
Annotations 0
Features 25
PDB binders 0
Druggability 0.892

Overview

Basic information about this protein and its source genome.

Accession
VK055_5081
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK83607.1
Status
annotated
Amino acids
629
Structure source
AlphaFold + ColabFold

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
85.22

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.892
Structure A4GZH1
Pocket Pocket 29
P2Rank 0.87
Structure A4GZH1
Pocket Pocket 1
ColabFold model
FPocket 0.517 · Pocket 40
P2Rank 0.901 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 10 / 4744 genomes with a hit
Normalized 0.002

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

No GO or EC annotations are currently loaded for this protein.

Sequence Features

Domain/signature hits from InterPro and related databases.

25 records
Show feature table
Start End DB Term Name
104 126 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
306 567 Gene3D G3DSA:3.40.50.300 -
306 567 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
168 545 SUPERFAMILY SSF52540 P-loop containing nucleoside triphosphate hydrolases
168 545 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
105 125 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
7 616 PIRSF PIRSF003273 Mobilization_A
7 616 InterPro IPR016387 Mobilization, MobA
613 629 MobiDBLite mobidb-lite consensus disorder prediction
414 552 Pfam PF10412 Type IV secretion-system coupling protein DNA-binding domain
414 552 InterPro IPR019476 Type IV secretion system coupling protein TraD, DNA-binding domain
39 57 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
12 33 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
69 91 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
58 68 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
69 93 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
10 32 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
172 289 Gene3D G3DSA:3.40.50.300 -
172 289 InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
39 54 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
94 104 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
34 38 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
597 629 MobiDBLite mobidb-lite consensus disorder prediction
126 629 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1 11 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A4GZH1
AlphaFold — — full sequence — Viewing
ColabFold VK055_5081
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
29 0.892
37 0.246

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 15.46 0.754
2 1.68 0.029
3 1.17 0.01
4 1.16 0.009