Protein profile

VK055_5165

chitinase class I family protein

Genome: KpATCC43816

Gene: AIK83686.1 Structure source: AlphaFold + ColabFold UniProt A0A6B2HFN5
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Amino acids 209
Annotations 3
Features 6
PDB binders 0
Druggability 0.125

Overview

Basic information about this protein and its source genome.

Accession
VK055_5165
Assembly
Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome
Gene
AIK83686.1
Status
annotated
Amino acids
209
Structure source
AlphaFold + ColabFold
GO
GO:0006032 The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues. GO:0004568 Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins. GO:0016998 The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
37.968
Localization
Unknown
ColabFold pLDDT
97.36

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.125
Structure A0A6B2HFN5
Pocket Pocket 3
P2Rank 0.055
Structure A0A6B2HFN5
Pocket Pocket 1
ColabFold model
FPocket 0.434 · Pocket 3
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 26 / 4744 genomes with a hit
Normalized 0.005

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0006032 The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues.
  • GO:0004568 Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins.
  • GO:0016998 The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall.

Sequence Features

Domain/signature hits from InterPro and related databases.

6 records
Show feature table
Start End DB Term Name
2 207 PANTHER PTHR34408 FAMILY PROTEIN, PUTATIVE-RELATED
3 207 SUPERFAMILY SSF53955 Lysozyme-like
3 207 InterPro IPR023346 Lysozyme-like domain superfamily
6 207 Gene3D G3DSA:1.10.530.10 -
112 172 Pfam PF00182 Chitinase class I
112 172 InterPro IPR000726 Glycoside hydrolase, family 19, catalytic

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A6B2HFN5
AlphaFold — — full sequence — Viewing
ColabFold VK055_5165
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.91 0.039