Protein profile

KP13_00056

2-oxo-3-deoxygalactonate kinase

Genome: KpKP13

Gene: AHE41980.1 dgoK Structure source: Experimental + ColabFold UniProt A6TFZ6
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Amino acids 292
Annotations 2
Features 6
PDB binders 0
Druggability 0.709

Overview

Basic information about this protein and its source genome.

Accession
KP13_00056
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE41980.1 dgoK
Status
annotated
Amino acids
292
Structure source
Experimental + ColabFold
GO
GO:0008671 Catalysis of the reaction: 2-dehydro-3-deoxy-D-galactonate + ATP = 6-phospho-2-dehydro-3-deoxy-D-galactonate + ADP + 2 H+. GO:0034194 The chemical reactions and pathways resulting in the breakdown of D-galactonate, the anion of D-galactonic acid.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
97.53

Selected Druggability evidence

PDB experimental structure

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.709
Structure 3R1X
Pocket Pocket 3
P2Rank 0.156
Structure 3R1X
Pocket Pocket 1
ColabFold model
FPocket 0.473 · Pocket 5
P2Rank 0.38 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 50 / 4744 genomes with a hit
Normalized 0.011

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0008671 Catalysis of the reaction: 2-dehydro-3-deoxy-D-galactonate + ATP = 6-phospho-2-dehydro-3-deoxy-D-galactonate + ADP + 2 H+.
  • GO:0034194 The chemical reactions and pathways resulting in the breakdown of D-galactonate, the anion of D-galactonic acid.

Sequence Features

Domain/signature hits from InterPro and related databases.

6 records
Show feature table
Start End DB Term Name
90 292 Gene3D G3DSA:3.30.420.310 -
90 292 InterPro IPR042257 2-keto-3-deoxy-galactonokinase, C-terminal domain
1 76 Gene3D G3DSA:3.30.420.300 -
1 76 InterPro IPR042258 2-keto-3-deoxy-galactonokinase, N-terminal
9 286 Pfam PF05035 2-keto-3-deoxy-galactonokinase
9 286 InterPro IPR007729 2-keto-3-deoxy-galactonokinase

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 3R1X
X-ray 20.00 Å - —
PDBe RCSB PDBj File
Viewing
ColabFold KP13_00056
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
75 0.958
15 0.668
44 0.294

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 10.64 0.571
2 10.2 0.548
3 10.15 0.546
4 9.0 0.482
5 8.39 0.447