Protein profile

KP13_00063

Small heat shock protein ibpA

Genome: KpKP13

Gene: AHE41987.1 ibpA Structure source: AlphaFold + ColabFold UniProt A0A0H3GZ02
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Amino acids 152
Annotations 2
Features 14
PDB binders 0
Druggability 0.401

Overview

Basic information about this protein and its source genome.

Accession
KP13_00063
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE41987.1 ibpA
Status
annotated
Amino acids
152
Structure source
AlphaFold + ColabFold
GO
GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0050821 Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
75.71

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.401
Structure A0A0H3GZ02
Pocket Pocket 8
P2Rank 0.009
Structure A0A0H3GZ02
Pocket Pocket 1
ColabFold model
FPocket 0.068 · Pocket 18
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 119 / 4744 genomes with a hit
Normalized 0.025

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0050821 Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records
Show feature table
Start End DB Term Name
16 152 Hamap MF_02000 Small heat shock protein IbpA [ibpA].
16 152 InterPro IPR023728 Small heat shock protein IbpA
45 152 SUPERFAMILY SSF49764 HSP20-like chaperones
45 152 InterPro IPR008978 HSP20-like chaperone
48 152 FunFam G3DSA:2.60.40.790:FF:000002 Small heat shock protein IbpA
43 152 ProSiteProfiles PS01031 Small heat shock protein (sHSP) domain profile.
43 152 InterPro IPR002068 Alpha crystallin/Hsp20 domain
16 152 PANTHER PTHR47062 -
50 138 CDD cd06470 ACD_IbpA-B_like
50 138 InterPro IPR037913 Small heat shock protein IbpA/IbpB, ACD domain
48 152 Gene3D G3DSA:2.60.40.790 -
48 152 InterPro IPR008978 HSP20-like chaperone
56 152 Pfam PF00011 Hsp20/alpha crystallin family
56 152 InterPro IPR002068 Alpha crystallin/Hsp20 domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GZ02
AlphaFold — — full sequence — Viewing
ColabFold KP13_00063
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
8 0.401

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.23 0.012