Protein profile

KP13_07457

RCK domain-containing protein

Genome: KpKP13

Gene: ANJ86557.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3H4T9

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Amino acids 553

Annotations 3

Features 60

PDB binders 0

Druggability 0.817

Overview

Basic information about this protein and its source genome.

Accession: KP13_07457
Assembly: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene: ANJ86557.1
Status: annotated
Amino acids: 553
Structure source: AlphaFold + ColabFold

GO:0006813 The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0008324 Enables the transfer of cation from one side of a membrane to the other. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target: No hit
Human identity (%): 0.0
Gut microbiome off-target: hit
Essential (DEG): Y
DEG identity (%): 65.455
DEG E-value: 0.0
Localization: CytoplasmicMembrane
ColabFold pLDDT: 87.64

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.817

Structure A0A0H3H4T9

Pocket Pocket 20

P2Rank 0.772

Structure A0A0H3H4T9

Pocket Pocket 1

ColabFold model

FPocket 0.58 · Pocket 27

P2Rank 0.708 · Pocket 1

Core conservation Conserved core gene

Roary core

CoreCruncher core

Gut microbiome 119 / 4744 genomes with a hit

Normalized 0.025

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

GO:0006813 The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
GO:0008324 Enables the transfer of cation from one side of a membrane to the other.
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

60 records

Show feature table

Start	End	DB	Term	Name
6	22	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
492	514	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
286	360	SUPERFAMILY	SSF116726	TrkA C-terminal domain-like
286	360	InterPro	IPR036721	Regulator of K+ conductance, C-terminal domain superfamily
437	458	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
371	391	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
61	83	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
426	436	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
463	485	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
28	46	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
464	485	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
514	532	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
116	161	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
90	112	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
29	47	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
48	66	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
203	271	SUPERFAMILY	SSF116726	TrkA C-terminal domain-like
203	271	InterPro	IPR036721	Regulator of K+ conductance, C-terminal domain superfamily
183	370	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
205	272	Gene3D	G3DSA:3.30.70.1450	-
205	272	InterPro	IPR036721	Regulator of K+ conductance, C-terminal domain superfamily
87	92	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
1	5	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
279	361	ProSiteProfiles	PS51202	RCK C-terminal domain profile.
279	361	InterPro	IPR006037	Regulator of K+ conductance, C-terminal
352	372	Coils	Coil	Coil
437	459	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
4	21	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
192	276	ProSiteProfiles	PS51202	RCK C-terminal domain profile.
192	276	InterPro	IPR006037	Regulator of K+ conductance, C-terminal
403	425	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
93	115	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
23	28	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
67	86	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
371	393	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
403	425	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
11	179	Pfam	PF06826	Predicted Permease Membrane Region
11	179	InterPro	IPR006512	YidE/YbjL duplication
374	546	Pfam	PF06826	Predicted Permease Membrane Region
374	546	InterPro	IPR006512	YidE/YbjL duplication
392	402	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
533	552	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
288	361	Gene3D	G3DSA:3.30.70.1450	-
288	361	InterPro	IPR036721	Regulator of K+ conductance, C-terminal domain superfamily
492	513	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
486	491	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
15	551	PANTHER	PTHR30445	UNCHARACTERIZED
459	463	Phobius	NON_CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
160	182	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
292	360	Pfam	PF02080	TrkA-C domain
292	360	InterPro	IPR006037	Regulator of K+ conductance, C-terminal
553	553	Phobius	CYTOPLASMIC_DOMAIN	Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
529	551	TMHMM	TMhelix	Region of a membrane-bound protein predicted to be embedded in the membrane.
16	166	NCBIfam	TIGR01625	AspT/YidE/YbjL antiporter duplication domain
16	166	InterPro	IPR006512	YidE/YbjL duplication
379	533	NCBIfam	TIGR01625	AspT/YidE/YbjL antiporter duplication domain
379	533	InterPro	IPR006512	YidE/YbjL duplication
162	182	Phobius	TRANSMEMBRANE	Region of a membrane-bound protein predicted to be embedded in the membrane.
1	553	Hamap	MF_01016	Putative transport protein YidE [yidE].
1	553	InterPro	IPR023018	Transport protein YidE, putative

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold AF_A0A0H3H4T9	AlphaFold	—	—	full sequence	—	Viewing
ColabFold KP13_07457	ColabFold	—	—	full sequence	—	Loaded

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
20				0.817
33				0.395
25				0.375
13				0.226

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK	Score	Probability
1	14.55	0.726
2	4.66	0.203
3	4.47	0.19
4	3.7	0.141
5	3.66	0.138

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
27				0.58
34				0.559
2				0.432

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK	Score	Probability
1	11.63	0.619
2	4.8	0.213
3	4.16	0.169
4	4.15	0.168
5	2.69	0.08