Protein profile

KP13_00088

transcriptional regulator

Genome: KpKP13

Gene: AHE42013.1 Structure source: AlphaFold + ColabFold UniProt A0A232J6S0
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Amino acids 107
Annotations 1
Features 12
PDB binders 0
Druggability 0.29

Overview

Basic information about this protein and its source genome.

Accession
KP13_00088
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42013.1
Status
annotated
Amino acids
107
Structure source
AlphaFold + ColabFold
GO
GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
91.77

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.29
Structure A0A232J6S0
Pocket Pocket 2
P2Rank 0
Structure A0A232J6S0
Pocket –
ColabFold model
FPocket 0.516 · Pocket 4
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 20 / 4744 genomes with a hit
Normalized 0.004

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
52 88 CDD cd00093 HTH_XRE
52 88 InterPro IPR001387 Cro/C1-type helix-turn-helix domain
6 104 PANTHER PTHR36511 MERR FAMILY BACTERIAL REGULATORY PROTEIN
52 96 Pfam PF01381 Helix-turn-helix
52 96 InterPro IPR001387 Cro/C1-type helix-turn-helix domain
52 88 ProSiteProfiles PS50943 Cro/C1-type HTH domain profile.
52 106 SUPERFAMILY SSF47413 lambda repressor-like DNA-binding domains
52 106 InterPro IPR010982 Lambda repressor-like, DNA-binding domain superfamily
43 104 Gene3D G3DSA:1.10.260.40 -
43 104 InterPro IPR010982 Lambda repressor-like, DNA-binding domain superfamily
51 105 SMART SM00530 mbf_short4
51 105 InterPro IPR001387 Cro/C1-type helix-turn-helix domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A232J6S0
AlphaFold — — full sequence — Viewing
ColabFold KP13_00088
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.29

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 0.61 0.0