Protein profile

KP13_00125

TetR-like transcription regulator

Genome: KpKP13

Gene: AHE42045.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3H0A5
Export view
Amino acids 215
Annotations 3
Features 16
PDB binders 0
Druggability 0.63

Overview

Basic information about this protein and its source genome.

Accession
KP13_00125
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42045.1
Status
annotated
Amino acids
215
Structure source
AlphaFold + ColabFold
GO
GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976 Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
87.22

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.63
Structure A0A0H3H0A5
Pocket Pocket 2
P2Rank 0.895
Structure A0A0H3H0A5
Pocket Pocket 1
ColabFold model
FPocket 0.86 · Pocket 9
P2Rank 0.909 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 20 / 4744 genomes with a hit
Normalized 0.004

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
  • GO:0000976 Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records
Show feature table
Start End DB Term Name
1 24 MobiDBLite mobidb-lite consensus disorder prediction
8 24 MobiDBLite mobidb-lite consensus disorder prediction
18 93 SUPERFAMILY SSF46689 Homeodomain-like
18 93 InterPro IPR009057 Homeobox-like domain superfamily
97 213 SUPERFAMILY SSF48498 Tetracyclin repressor-like, C-terminal domain
97 213 InterPro IPR036271 Tetracyclin repressor-like, C-terminal domain superfamily
23 83 ProSiteProfiles PS50977 TetR-type HTH domain profile.
23 83 InterPro IPR001647 DNA-binding HTH domain, TetR-type
12 213 PANTHER PTHR30055 HTH-TYPE TRANSCRIPTIONAL REGULATOR RUTR
29 42 PRINTS PR00455 TetR bacterial regulatory protein HTH signature
29 42 InterPro IPR001647 DNA-binding HTH domain, TetR-type
50 73 PRINTS PR00455 TetR bacterial regulatory protein HTH signature
50 73 InterPro IPR001647 DNA-binding HTH domain, TetR-type
30 73 Pfam PF00440 Bacterial regulatory proteins, tetR family
30 73 InterPro IPR001647 DNA-binding HTH domain, TetR-type
19 214 Gene3D G3DSA:1.10.357.10 Tetracycline Repressor, domain 2

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3H0A5
AlphaFold — — full sequence — Viewing
ColabFold KP13_00125
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.63
1 0.0
12 0.0
17 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 29.22 0.895
2 2.81 0.07
3 1.25 0.01
4 1.11 0.007