Protein profile

KP13_00130

putative peroxidase-related protein

Genome: KpKP13

Gene: AHE42049.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3H0A3
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Amino acids 178
Annotations 1
Features 11
PDB binders 0
Druggability 0.648

Overview

Basic information about this protein and its source genome.

Accession
KP13_00130
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42049.1
Status
annotated
Amino acids
178
Structure source
AlphaFold + ColabFold
GO
GO:0051920 Catalysis of the reaction: [protein]-dithol + ROOH = [protein]-disulfide + H2O + ROH.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
96.9

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.648
Structure A0A0H3H0A3
Pocket Pocket 1
P2Rank 0.923
Structure A0A0H3H0A3
Pocket Pocket 1
ColabFold model
FPocket 0.706 · Pocket 1
P2Rank 0.896 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 19 / 4744 genomes with a hit
Normalized 0.004

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0051920 Catalysis of the reaction: [protein]-dithol + ROOH = [protein]-disulfide + H2O + ROH.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
15 176 Gene3D G3DSA:1.20.1290.10 -
15 176 InterPro IPR029032 AhpD-like
2 172 PANTHER PTHR35446 SI:CH211-175M2.5
51 104 Pfam PF02627 Carboxymuconolactone decarboxylase family
51 104 InterPro IPR003779 Carboxymuconolactone decarboxylase-like
1 176 SUPERFAMILY SSF69118 AhpD-like
1 176 InterPro IPR029032 AhpD-like
2 171 NCBIfam TIGR01926 peroxidase-related enzyme
2 171 InterPro IPR010195 Uncharacterised peroxidase-related
58 105 NCBIfam TIGR00778 alkylhydroperoxidase AhpD family core domain
58 105 InterPro IPR004675 Alkylhydroperoxidase AhpD core

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3H0A3
AlphaFold — — full sequence — Viewing
ColabFold KP13_00130
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.648

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 22.92 0.884
2 1.1 0.007