Protein profile

KP13_00131

AraC-type regulatory protein

Genome: KpKP13

Gene: AHE42050.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GUZ4
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Amino acids 301
Annotations 3
Features 25
PDB binders 0
Druggability 0.336

Overview

Basic information about this protein and its source genome.

Accession
KP13_00131
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42050.1
Status
annotated
Amino acids
301
Structure source
AlphaFold + ColabFold
GO
GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
93.4

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.336
Structure A0A0H3GUZ4
Pocket Pocket 17
P2Rank 0.19
Structure A0A0H3GUZ4
Pocket Pocket 1
ColabFold model
FPocket 0.478 · Pocket 4
P2Rank 0.422 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 16 / 4744 genomes with a hit
Normalized 0.003

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0043565 Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.

Sequence Features

Domain/signature hits from InterPro and related databases.

25 records
Show feature table
Start End DB Term Name
33 300 PANTHER PTHR46796 HTH-TYPE TRANSCRIPTIONAL ACTIVATOR RHAS-RELATED
198 248 SUPERFAMILY SSF46689 Homeodomain-like
198 248 InterPro IPR009057 Homeobox-like domain superfamily
199 256 Gene3D G3DSA:1.10.10.60 -
221 300 Pfam PF12833 Helix-turn-helix domain
221 300 InterPro IPR018060 DNA binding HTH domain, AraC-type
283 299 PRINTS PR00032 AraC bacterial regulatory protein HTH signature
283 299 InterPro IPR020449 Transcription regulator HTH, AraC- type
268 283 PRINTS PR00032 AraC bacterial regulatory protein HTH signature
268 283 InterPro IPR020449 Transcription regulator HTH, AraC- type
215 299 SMART SM00342 aracneu4
215 299 InterPro IPR018060 DNA binding HTH domain, AraC-type
26 81 Gene3D G3DSA:2.60.120.10 Jelly Rolls
26 81 InterPro IPR014710 RmlC-like jelly roll fold
199 301 ProSiteProfiles PS01124 Bacterial regulatory proteins, araC family DNA-binding domain profile.
199 301 InterPro IPR018060 DNA binding HTH domain, AraC-type
251 300 SUPERFAMILY SSF46689 Homeodomain-like
251 300 InterPro IPR009057 Homeobox-like domain superfamily
257 301 Gene3D G3DSA:1.10.10.60 -
2 182 Pfam PF12852 Cupin
2 182 InterPro IPR032783 AraC-type transcription regulator, ligand-binding domain
24 83 SUPERFAMILY SSF51182 RmlC-like cupins
24 83 InterPro IPR011051 RmlC-like cupin domain superfamily
252 295 ProSitePatterns PS00041 Bacterial regulatory proteins, araC family signature.
252 295 InterPro IPR018062 HTH domain AraC-type, conserved site

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GUZ4
AlphaFold — — full sequence — Viewing
ColabFold KP13_00131
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
17 0.336
3 0.253

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 3.12 0.105
2 2.53 0.071
3 1.26 0.013
4 1.07 0.007