Protein profile

KP13_00135

beta-lactamase domain-containing protein

Genome: KpKP13

Gene: AHE42054.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3H0A1
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Amino acids 259
Annotations 1
Features 9
PDB binders 0
Druggability 0.226

Overview

Basic information about this protein and its source genome.

Accession
KP13_00135
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42054.1
Status
annotated
Amino acids
259
Structure source
AlphaFold + ColabFold
GO
GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
98.46

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.226
Structure A0A0H3H0A1
Pocket Pocket 4
P2Rank 0.638
Structure A0A0H3H0A1
Pocket Pocket 1
ColabFold model
FPocket 0.555 · Pocket 1
P2Rank 0.647 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 61 / 4744 genomes with a hit
Normalized 0.013

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
1 259 Gene3D G3DSA:3.60.15.10 -
1 259 InterPro IPR036866 Ribonuclease Z/Hydroxyacylglutathione hydrolase-like
6 221 SMART SM00849 Lactamase_B_5a
6 221 InterPro IPR001279 Metallo-beta-lactamase
19 221 Pfam PF12706 Beta-lactamase superfamily domain
19 221 InterPro IPR001279 Metallo-beta-lactamase
2 259 PANTHER PTHR43546 UPF0173 METAL-DEPENDENT HYDROLASE MJ1163-RELATED
1 247 SUPERFAMILY SSF56281 Metallo-hydrolase/oxidoreductase
1 247 InterPro IPR036866 Ribonuclease Z/Hydroxyacylglutathione hydrolase-like

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3H0A1
AlphaFold — — full sequence — Viewing
ColabFold KP13_00135
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
4 0.226

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 10.14 0.545
2 0.97 0.005