Protein profile

KP13_00144

RpiR family transcriptional regulator protein

Genome: KpKP13

Gene: AHE42064.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GYU8
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Amino acids 240
Annotations 5
Features 17
PDB binders 0
Druggability 0.827

Overview

Basic information about this protein and its source genome.

Accession
KP13_00144
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42064.1
Status
annotated
Amino acids
240
Structure source
AlphaFold + ColabFold
GO
GO:1901135 The chemical reactions and pathways involving carbohydrate derivative. GO:0097367 Binding to a carbohydrate derivative. GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
91.12

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.827
Structure A0A0H3GYU8
Pocket Pocket 12
P2Rank 0.257
Structure A0A0H3GYU8
Pocket Pocket 1
ColabFold model
FPocket 0.563 · Pocket 3
P2Rank 0.071 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 18 / 4744 genomes with a hit
Normalized 0.004

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:1901135 The chemical reactions and pathways involving carbohydrate derivative.
  • GO:0097367 Binding to a carbohydrate derivative.
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

17 records
Show feature table
Start End DB Term Name
8 75 Gene3D G3DSA:1.10.10.10 -
8 75 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
101 206 SUPERFAMILY SSF53697 SIS domain
101 206 InterPro IPR046348 SIS domain superfamily
102 208 PANTHER PTHR30514 GLUCOKINASE
102 208 InterPro IPR047640 HTH-type transcriptional regulator RpiR-like
11 65 Pfam PF01418 Helix-turn-helix domain, rpiR family
11 65 InterPro IPR000281 Helix-turn-helix protein RpiR
11 71 SUPERFAMILY SSF46689 Homeodomain-like
11 71 InterPro IPR009057 Homeobox-like domain superfamily
77 215 Gene3D G3DSA:3.40.50.10490 -
1 75 ProSiteProfiles PS51071 RpiR-type HTH domain profile.
1 75 InterPro IPR000281 Helix-turn-helix protein RpiR
92 208 CDD cd05013 SIS_RpiR
92 208 InterPro IPR035472 RpiR-like, SIS domain
102 205 Pfam PF01380 SIS domain
102 205 InterPro IPR001347 SIS domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GYU8
AlphaFold — — full sequence — Viewing
ColabFold KP13_00144
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
12 0.827

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.24 0.055