Protein profile

KP13_31756

sodium/glutamate symporter

Genome: KpKP13

Gene: gltS AHE42069.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3H088
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Amino acids 400
Annotations 4
Features 44
PDB binders 0
Druggability 0.803

Overview

Basic information about this protein and its source genome.

Accession
KP13_31756
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
gltS AHE42069.1
Status
annotated
Amino acids
400
Structure source
AlphaFold + ColabFold
GO
GO:0015501 Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glutamate(out) + Na+(out) = glutamate(in) + Na+(in). GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015813 The directed movement of L-glutamate across a membrane by means of some agent such as a transporter or a pore. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
89.97

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.803
Structure A0A0H3H088
Pocket Pocket 1
P2Rank 0.887
Structure A0A0H3H088
Pocket Pocket 1
ColabFold model
FPocket 0.447 · Pocket 25
P2Rank 0.923 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 154 / 4744 genomes with a hit
Normalized 0.032

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4
  • GO:0015501 Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glutamate(out) + Na+(out) = glutamate(in) + Na+(in).
  • GO:0016020 A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
  • GO:0015813 The directed movement of L-glutamate across a membrane by means of some agent such as a transporter or a pore.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Sequence Features

Domain/signature hits from InterPro and related databases.

44 records
Show feature table
Start End DB Term Name
266 276 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
7 19 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
34 52 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
157 179 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
120 125 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
240 244 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
245 267 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
1 6 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
2 399 PANTHER PTHR36178 SLR0625 PROTEIN
2 399 InterPro IPR004445 Sodium/glutamate symport carrier protein GltS
1 24 Phobius SIGNAL_PEPTIDE Signal peptide region
215 239 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
298 302 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
20 24 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
53 71 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
92 96 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
358 368 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
303 323 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
369 396 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
2 366 Pfam PF03616 Sodium/glutamate symporter
2 366 InterPro IPR004445 Sodium/glutamate symport carrier protein GltS
70 87 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
94 116 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
337 359 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
397 400 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
274 292 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
324 334 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
335 357 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
208 230 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
2 397 NCBIfam TIGR00210 sodium/glutamate symporter
2 397 InterPro IPR004445 Sodium/glutamate symport carrier protein GltS
1 397 Hamap MF_02062 Sodium/glutamate symporter [gltS].
1 397 InterPro IPR004445 Sodium/glutamate symport carrier protein GltS
126 148 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
277 297 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
25 33 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
302 324 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
72 91 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
149 159 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
374 396 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
245 265 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
97 119 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.
185 214 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
160 184 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3H088
AlphaFold — — full sequence — Viewing
ColabFold KP13_31756
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.803
7 0.548
9 0.222

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 16.89 0.79
2 2.0 0.043
3 1.94 0.04
4 1.91 0.039
5 1.9 0.038