Protein profile

KP13_00172

YicC-like domain-containing protein

Genome: KpKP13

Gene: AHE42092.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GXE6
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Amino acids 287
Annotations 2
Features 9
PDB binders 0
Druggability 0.742

Overview

Basic information about this protein and its source genome.

Accession
KP13_00172
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42092.1
Status
annotated
Amino acids
287
Structure source
AlphaFold + ColabFold
GO
GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0004521 Catalysis of the cleavage of ester linkages within ribonucleic acid by creating internal breaks.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
64.111
DEG E-value
2.44e-135
Localization
Cytoplasmic
ColabFold pLDDT
88.36

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.742
Structure A0A0H3GXE6
Pocket Pocket 2
P2Rank
Structure A0A0H3GXE6
Pocket No pockets
ColabFold model
FPocket 0.586 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 149 / 4744 genomes with a hit
Normalized 0.031

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0016787 Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
  • GO:0004521 Catalysis of the cleavage of ester linkages within ribonucleic acid by creating internal breaks.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
182 218 Coils Coil Coil
1 287 PANTHER PTHR30636 UNCHARACTERIZED
1 287 InterPro IPR005229 UPF0701 protein YicC-like
203 287 Pfam PF08340 Domain of unknown function (DUF1732)
203 287 InterPro IPR013551 Domain of unknown function DUF1732
1 287 NCBIfam TIGR00255 YicC family protein
2 153 Pfam PF03755 YicC-like family, N-terminal region
2 153 InterPro IPR013527 YicC-like, N-terminal
269 287 Coils Coil Coil

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GXE6
AlphaFold — — full sequence — Viewing
ColabFold KP13_00172
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.742