Protein profile

KP13_00173

Acyl-CoA N-acyltransferase domain-containing protein

Genome: KpKP13

Gene: AHE42093.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3H063
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Amino acids 566
Annotations 3
Features 9
PDB binders 0
Druggability 0.962

Overview

Basic information about this protein and its source genome.

Accession
KP13_00173
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42093.1
Status
annotated
Amino acids
566
Structure source
AlphaFold + ColabFold
EC
2.3.2.30
GO
GO:0043810 Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + L-ornithine = lyso-ornithine lipid + [acyl-carrier protein]. The enzyme, found in bacteria, catalyzes the first step in the biosynthesis of ornithine lipids. GO:0006629 The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
89.64

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.962
Structure A0A0H3H063
Pocket Pocket 27
P2Rank 0.982
Structure A0A0H3H063
Pocket Pocket 1
ColabFold model
FPocket 0.879 · Pocket 6
P2Rank 0.988 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 3 / 4744 genomes with a hit
Normalized 0.001

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 2 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

2
  • GO:0043810 Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + L-ornithine = lyso-ornithine lipid + [acyl-carrier protein]. The enzyme, found in bacteria, catalyzes the first step in the biosynthesis of ornithine lipids.
  • GO:0006629 The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.

Sequence Features

Domain/signature hits from InterPro and related databases.

9 records
Show feature table
Start End DB Term Name
306 447 SUPERFAMILY SSF55729 Acyl-CoA N-acyltransferases (Nat)
306 447 InterPro IPR016181 Acyl-CoA N-acyltransferase
283 565 PANTHER PTHR37323 GCN5-RELATED N-ACETYLTRANSFERASE
57 253 CDD cd07986 LPLAT_ACT14924-like
57 253 InterPro IPR045746 Putative acyltransferase ACT14924-like, acyltransferase domain
67 263 SUPERFAMILY SSF69593 Glycerol-3-phosphate (1)-acyltransferase
325 426 Pfam PF13444 Acetyltransferase (GNAT) domain
23 242 Pfam PF19576 Acyltransferase
23 242 InterPro IPR045746 Putative acyltransferase ACT14924-like, acyltransferase domain

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3H063
AlphaFold — — full sequence — Viewing
ColabFold KP13_00173
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
27 0.962
28 0.372

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 46.13 0.974
2 18.21 0.817
3 5.41 0.257
4 4.46 0.189
5 2.15 0.05