Protein profile

KP13_00182

HTH-type protein slmA

Genome: KpKP13

Gene: slmA AHE42097.1 Structure source: Experimental + ColabFold UniProt A6TFN2
Export view
Amino acids 198
Annotations 2
Features 16
PDB binders 0
Druggability 0.11

Overview

Basic information about this protein and its source genome.

Accession
KP13_00182
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
slmA AHE42097.1
Status
annotated
Amino acids
198
Structure source
Experimental + ColabFold
GO
GO:0010974 Any process that decreases the frequency, rate or extent of division septum formation. division septum formation is he assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
95.02

Selected Druggability evidence

PDB experimental structure

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.11
Structure 5HSZ
Pocket Pocket 2
P2Rank
Structure 5HSZ
Pocket No pockets
ColabFold model
FPocket 0.487 · Pocket 2
P2Rank 0.038 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 125 / 4744 genomes with a hit
Normalized 0.026

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0010974 Any process that decreases the frequency, rate or extent of division septum formation. division septum formation is he assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

16 records
Show feature table
Start End DB Term Name
20 61 Pfam PF00440 Bacterial regulatory proteins, tetR family
20 61 InterPro IPR001647 DNA-binding HTH domain, TetR-type
1 198 Hamap MF_01839 Nucleoid occlusion factor SlmA [slmA].
1 198 InterPro IPR023769 Nucleoid occlusion factor SlmA
3 193 PANTHER PTHR30055 HTH-TYPE TRANSCRIPTIONAL REGULATOR RUTR
9 198 FunFam G3DSA:1.10.357.10:FF:000002 Nucleoid occlusion factor SlmA
9 198 Gene3D G3DSA:1.10.357.10 Tetracycline Repressor, domain 2
84 192 SUPERFAMILY SSF48498 Tetracyclin repressor-like, C-terminal domain
84 192 InterPro IPR036271 Tetracyclin repressor-like, C-terminal domain superfamily
5 86 SUPERFAMILY SSF46689 Homeodomain-like
5 86 InterPro IPR009057 Homeobox-like domain superfamily
118 138 Coils Coil Coil
28 58 ProSitePatterns PS01081 TetR-type HTH domain signature.
28 58 InterPro IPR023772 DNA-binding HTH domain, TetR-type, conserved site
10 70 ProSiteProfiles PS50977 TetR-type HTH domain profile.
10 70 InterPro IPR001647 DNA-binding HTH domain, TetR-type

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

Legend High Medium Low

Structural evidence

1 + 1

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
PDB 5HSZ
X-ray 20.00 Å - —
PDBe RCSB PDBj File
Viewing
ColabFold KP13_00182
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.586

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.55 0.072
2 2.05 0.045
3 1.4 0.018
4 1.11 0.008