Target Pathogen

Overview

Basic information about this protein and its source genome.

Accession: KP13_00187
Assembly: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene: AHE42101.1 rpmG
Status: annotated
Amino acids: 55
Structure source: AlphaFold + ColabFold

GO

GO:0003735 The action of a molecule that contributes to the structural integrity of the ribosome. GO:0005840 An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. GO:0006412 The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. GO:0022625 The large subunit of a ribosome located in the cytosol.

Target profile

Computed evidence for target prioritization.

Human off-target: hit
Human identity (%): 44.444
Human E-value: 3.45e-07
Gut microbiome off-target: hit
Essential (DEG): Y
DEG identity (%): 96.364
DEG E-value: 3.81e-34
Localization: Cytoplasmic
ColabFold pLDDT: 85.25

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.28

Structure A0A0H3GYS8

Pocket Pocket 1

P2Rank

Structure A0A0H3GYS8

Pocket No pockets

ColabFold model

FPocket 0.154 · Pocket 1

Core conservation Conserved core gene

Roary core

CoreCruncher core

Gut microbiome 369 / 4744 genomes with a hit

Normalized 0.078

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

4 GO

Gene Ontology (GO)

4

GO:0003735 The action of a molecule that contributes to the structural integrity of the ribosome.
GO:0005840 An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins.
GO:0006412 The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.
GO:0022625 The large subunit of a ribosome located in the cytosol.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records

Show feature table

Start	End	DB	Term	Name
3	55	PANTHER	PTHR15238	54S RIBOSOMAL PROTEIN L39, MITOCHONDRIAL
21	40	ProSitePatterns	PS00582	Ribosomal protein L33 signature.
21	40	InterPro	IPR018264	Ribosomal protein L33, conserved site
1	53	SUPERFAMILY	SSF57829	Zn-binding ribosomal proteins
1	53	InterPro	IPR011332	Zinc-binding ribosomal protein
1	55	FunFam	G3DSA:2.20.28.120:FF:000001	50S ribosomal protein L33
7	53	Pfam	PF00471	Ribosomal protein L33
7	53	InterPro	IPR001705	Ribosomal protein L33
5	53	Hamap	MF_00294	50S ribosomal protein L33 [rpmG].
5	53	InterPro	IPR001705	Ribosomal protein L33
1	55	Gene3D	G3DSA:2.20.28.120	Ribosomal protein L33
1	55	InterPro	IPR038584	Ribosomal protein L33 superfamily
1	55	NCBIfam	TIGR01023	50S ribosomal protein L33
1	55	InterPro	IPR001705	Ribosomal protein L33

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry	Method	Resolution	Chain	Coverage	Links	Status
AlphaFold AF_A0A0H3GYS8	AlphaFold	—	—	full sequence	—	Viewing
ColabFold KP13_00187	ColabFold	—	—	full sequence	—	Loaded

Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET	Sticks	Spheres	Surfaces	Druggability	Labels	Zoom	Positions
1				0.28

KP13_00187