Protein profile

KP13_00195

Lipopolysaccharide core heptosyltransferase rfaQ

Genome: KpKP13

Gene: rfaQ AHE42109.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3H4I2
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Amino acids 358
Annotations 5
Features 11
PDB binders 1
Druggability 0.725

Overview

Basic information about this protein and its source genome.

Accession
KP13_00195
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
rfaQ AHE42109.1
Status
annotated
Amino acids
358
Structure source
AlphaFold + ColabFold
EC
2.4.99.25
GO
GO:0016757 Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008713 Catalysis of the reaction: heptosyl-KDO2-lipid A + ADP-L-glycero-beta-D-manno-heptose = heptosyl2-KDO2-lipid A + ADP + H+. GO:0009244 The chemical reactions and pathways resulting in the formation of the core region of bacterial lipopolysaccharides, which contains ten saccharide residues.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
42.604
DEG E-value
3.23e-90
Localization
CytoplasmicMembrane
ColabFold pLDDT
94.52

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.725
Structure A0A0H3H4I2
Pocket Pocket 1
P2Rank 0.839
Structure A0A0H3H4I2
Pocket Pocket 1
ColabFold model
FPocket 0.092 · Pocket 15
P2Rank 0.854 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 53 / 4744 genomes with a hit
Normalized 0.011

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 4 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

4
  • GO:0016757 Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor).
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0008713 Catalysis of the reaction: heptosyl-KDO2-lipid A + ADP-L-glycero-beta-D-manno-heptose = heptosyl2-KDO2-lipid A + ADP + H+.
  • GO:0009244 The chemical reactions and pathways resulting in the formation of the core region of bacterial lipopolysaccharides, which contains ten saccharide residues.

Sequence Features

Domain/signature hits from InterPro and related databases.

11 records
Show feature table
Start End DB Term Name
13 357 PANTHER PTHR30160 TETRAACYLDISACCHARIDE 4'-KINASE-RELATED
15 358 NCBIfam TIGR02201 putative lipopolysaccharide heptosyltransferase III
15 358 InterPro IPR011916 Lipopolysaccharide heptosyltransferase III, putative
15 358 SUPERFAMILY SSF53756 UDP-Glycosyltransferase/glycogen phosphorylase
10 175 Gene3D G3DSA:3.40.50.2000 Glycogen Phosphorylase B;
14 173 FunFam G3DSA:3.40.50.2000:FF:000191 Lipopolysaccharide core heptosyltransferase RfaQ
182 358 Gene3D G3DSA:3.40.50.2000 Glycogen Phosphorylase B;
87 328 Pfam PF01075 Glycosyltransferase family 9 (heptosyltransferase)
87 328 InterPro IPR002201 Glycosyl transferase, family 9
15 355 CDD cd03789 GT9_LPS_heptosyltransferase
15 355 InterPro IPR002201 Glycosyl transferase, family 9

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3H4I2
AlphaFold — — full sequence — Viewing
ColabFold KP13_00195
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.725

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 8.69 0.465
2 8.37 0.446
3 4.66 0.203

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

51 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
AFH
2H1H
P24173 621.4 Da LogP -3.58 TPSA 311.7 3 viol. ✓ Clean c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)…

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.