Protein profile

KP13_00200

Lipopolysaccharide heptosyltransferase 1

Genome: KpKP13

Gene: AHE42114.1 rfaC Structure source: AlphaFold + ColabFold UniProt A0A0H3GYR9
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Amino acids 323
Annotations 7
Features 12
PDB binders 1
Druggability 0.118

Overview

Basic information about this protein and its source genome.

Accession
KP13_00200
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42114.1 rfaC
Status
annotated
Amino acids
323
Structure source
AlphaFold + ColabFold
EC
2.4.99.23
GO
GO:0009244 The chemical reactions and pathways resulting in the formation of the core region of bacterial lipopolysaccharides, which contains ten saccharide residues. GO:0016757 Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). GO:0008920 Catalysis of the reaction: a lipopolysaccharide + ADP-L-glycero-beta-D-manno-heptose = a heptosylated lipopolysaccharide + ADP + H+. GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0008713 Catalysis of the reaction: heptosyl-KDO2-lipid A + ADP-L-glycero-beta-D-manno-heptose = heptosyl2-KDO2-lipid A + ADP + H+.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
85.57
DEG E-value
0.0
Localization
Cytoplasmic
ColabFold pLDDT
95.12

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.118
Structure A0A0H3GYR9
Pocket Pocket 16
P2Rank 0.612
Structure A0A0H3GYR9
Pocket Pocket 1
ColabFold model
FPocket 0.416 · Pocket 1
P2Rank 0.693 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 137 / 4744 genomes with a hit
Normalized 0.029

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 6 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

6
  • GO:0009244 The chemical reactions and pathways resulting in the formation of the core region of bacterial lipopolysaccharides, which contains ten saccharide residues.
  • GO:0016757 Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor).
  • GO:0008920 Catalysis of the reaction: a lipopolysaccharide + ADP-L-glycero-beta-D-manno-heptose = a heptosylated lipopolysaccharide + ADP + H+.
  • GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0008713 Catalysis of the reaction: heptosyl-KDO2-lipid A + ADP-L-glycero-beta-D-manno-heptose = heptosyl2-KDO2-lipid A + ADP + H+.

Sequence Features

Domain/signature hits from InterPro and related databases.

12 records
Show feature table
Start End DB Term Name
1 302 SUPERFAMILY SSF53756 UDP-Glycosyltransferase/glycogen phosphorylase
164 319 Gene3D G3DSA:3.40.50.2000 Glycogen Phosphorylase B;
76 302 Pfam PF01075 Glycosyltransferase family 9 (heptosyltransferase)
76 302 InterPro IPR002201 Glycosyl transferase, family 9
1 163 Gene3D G3DSA:3.40.50.2000 Glycogen Phosphorylase B;
1 302 PANTHER PTHR30160 TETRAACYLDISACCHARIDE 4'-KINASE-RELATED
164 315 FunFam G3DSA:3.40.50.2000:FF:000106 Lipopolysaccharide heptosyltransferase 1
2 302 CDD cd03789 GT9_LPS_heptosyltransferase
2 302 InterPro IPR002201 Glycosyl transferase, family 9
2 319 NCBIfam TIGR02193 lipopolysaccharide heptosyltransferase I
2 319 InterPro IPR011908 Lipopolysaccharide heptosyltransferase I
1 163 FunFam G3DSA:3.40.50.2000:FF:000075 Lipopolysaccharide heptosyltransferase I

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GYR9
AlphaFold — — full sequence — Viewing
ColabFold KP13_00200
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 5.01 0.228
2 3.63 0.136
3 3.5 0.128

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

51 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
AFH
2H1H
P24173 621.4 Da LogP -3.58 TPSA 311.7 3 viol. ✓ Clean c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)…

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.