Protein profile

KP13_00205

putative glycosyltransferase, family 2

Genome: KpKP13

Gene: AHE42119.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GYR6
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Amino acids 262
Annotations 1
Features 14
PDB binders 0
Druggability 0.468

Overview

Basic information about this protein and its source genome.

Accession
KP13_00205
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42119.1
Status
annotated
Amino acids
262
Structure source
AlphaFold + ColabFold
GO
GO:0016740 Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
92.35

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.468
Structure A0A0H3GYR6
Pocket Pocket 1
P2Rank 0.732
Structure A0A0H3GYR6
Pocket Pocket 1
ColabFold model
FPocket 0.147 · Pocket 4
P2Rank 0.889 · Pocket 1
Core conservation Accessory gene
Roary core
CoreCruncher accessory
Gut microbiome 34 / 4744 genomes with a hit
Normalized 0.007

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0016740 Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.

Sequence Features

Domain/signature hits from InterPro and related databases.

14 records
Show feature table
Start End DB Term Name
1 16 SignalP_EUK SignalP-noTM SignalP-noTM
5 92 Pfam PF00535 Glycosyl transferase family 2
5 92 InterPro IPR001173 Glycosyltransferase 2-like
3 101 PANTHER PTHR43630 POLY-BETA-1,6-N-ACETYL-D-GLUCOSAMINE SYNTHASE
1 140 Gene3D G3DSA:3.90.550.10 Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A
1 140 InterPro IPR029044 Nucleotide-diphospho-sugar transferases
1 18 Phobius SIGNAL_PEPTIDE Signal peptide region
19 262 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 3 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
2 162 SUPERFAMILY SSF53448 Nucleotide-diphospho-sugar transferases
2 162 InterPro IPR029044 Nucleotide-diphospho-sugar transferases
12 18 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
3 226 CDD cd02511 Beta4Glucosyltransferase
4 11 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GYR6
AlphaFold — — full sequence — Viewing
ColabFold KP13_00205
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
1 0.468
17 0.213

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 12.87 0.665
2 9.37 0.503
3 4.9 0.22
4 1.41 0.018
5 1.26 0.013