Protein profile

KP13_00206

hypothetical protein

Genome: KpKP13

Gene: AHE42120.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3H033
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Amino acids 315
Annotations 1
Features 19
PDB binders 0
Druggability 0.35

Overview

Basic information about this protein and its source genome.

Accession
KP13_00206
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42120.1
Status
annotated
Amino acids
315
Structure source
AlphaFold + ColabFold
GO
GO:0005975 The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Unknown
ColabFold pLDDT
87.28

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.35
Structure A0A0H3H033
Pocket Pocket 12
P2Rank 0.521
Structure A0A0H3H033
Pocket Pocket 1
ColabFold model
FPocket 0.527 · Pocket 1
P2Rank 0.63 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 107 / 4744 genomes with a hit
Normalized 0.023

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0005975 The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.

Sequence Features

Domain/signature hits from InterPro and related databases.

19 records
Show feature table
Start End DB Term Name
28 237 Pfam PF04748 Divergent polysaccharide deacetylase
28 237 InterPro IPR006837 Divergent polysaccharide deacetylase
24 238 SUPERFAMILY SSF88713 Glycoside hydrolase/deacetylase
24 238 InterPro IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel
23 291 PANTHER PTHR30105 UNCHARACTERIZED YIBQ-RELATED
23 291 InterPro IPR006837 Divergent polysaccharide deacetylase
1 23 Phobius SIGNAL_PEPTIDE Signal peptide region
1 23 SignalP_EUK SignalP-noTM SignalP-noTM
1 6 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
24 315 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
236 265 MobiDBLite mobidb-lite consensus disorder prediction
7 18 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
7 29 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
236 275 MobiDBLite mobidb-lite consensus disorder prediction
25 237 CDD cd10936 CE4_DAC2
25 237 InterPro IPR006837 Divergent polysaccharide deacetylase
15 247 Gene3D G3DSA:3.20.20.370 Glycoside hydrolase/deacetylase
19 23 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
1 23 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3H033
AlphaFold — — full sequence — Viewing
ColabFold KP13_00206
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
12 0.35
4 0.22
19 0.203

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 5.96 0.293