Protein profile

KP13_31553

Peptidase M23 protein

Genome: KpKP13

Gene: AHE42121.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GUR0
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Amino acids 423
Annotations 1
Features 25
PDB binders 3
Druggability 0.621

Overview

Basic information about this protein and its source genome.

Accession
KP13_31553
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42121.1
Status
annotated
Amino acids
423
Structure source
AlphaFold + ColabFold
GO
GO:0004222 Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
56.429
DEG E-value
1.36e-155
Localization
OuterMembrane
ColabFold pLDDT
85.24

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.621
Structure A0A0H3GUR0
Pocket Pocket 10
P2Rank 0.786
Structure A0A0H3GUR0
Pocket Pocket 1
ColabFold model
FPocket 0.444 · Pocket 17
P2Rank 0.792 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 111 / 4744 genomes with a hit
Normalized 0.023

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 GO

Gene Ontology (GO)

1
  • GO:0004222 Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.

Sequence Features

Domain/signature hits from InterPro and related databases.

25 records
Show feature table
Start End DB Term Name
216 250 Coils Coil Coil
212 235 MobiDBLite mobidb-lite consensus disorder prediction
223 421 SUPERFAMILY SSF51261 Duplicated hybrid motif
223 421 InterPro IPR011055 Duplicated hybrid motif
282 423 Gene3D G3DSA:2.70.70.10 Glucose Permease (Domain IIA)
282 423 InterPro IPR011055 Duplicated hybrid motif
62 276 Gene3D G3DSA:6.10.250.3150 -
251 281 MobiDBLite mobidb-lite consensus disorder prediction
252 272 Coils Coil Coil
22 33 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
217 235 MobiDBLite mobidb-lite consensus disorder prediction
1 38 SignalP_GRAM_NEGATIVE SignalP-noTM SignalP-noTM
1 38 Phobius SIGNAL_PEPTIDE Signal peptide region
1 38 SignalP_GRAM_POSITIVE SignalP-TM SignalP-TM
325 408 CDD cd12797 M23_peptidase
39 423 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
1 21 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
44 127 Coils Coil Coil
49 422 PANTHER PTHR21666 PEPTIDASE-RELATED
34 38 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
251 291 MobiDBLite mobidb-lite consensus disorder prediction
288 423 FunFam G3DSA:2.70.70.10:FF:000003 Murein hydrolase activator EnvC
324 417 Pfam PF01551 Peptidase family M23
324 417 InterPro IPR016047 Peptidase M23
167 190 Coils Coil Coil

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

Loading 3D structure...

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GUR0
AlphaFold — — full sequence — Viewing
ColabFold KP13_31553
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
10 0.621
1 0.031
11 0.002
18 0.0

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 20.0 0.786
2 4.24 0.143
3 1.35 0.013

Ligand evidence

Ligands grouped by evidence source. PDB ligands keep the source crystal visible, and loaded crystals can be opened directly in the structure viewer.

22 records

Structural evidence inferred from similar proteins. The source crystal indicates where the ligand was observed; the UniProt column identifies the homologous protein carrying that ligand.

Show only:
Ligand Source crystal UniProt (homolog) MW · LogP · TPSA Lipinski PAINS SMILES
4SQ
4ZYB
O33599 281.2 Da LogP -2.12 TPSA 158.8 ✓ Ro5 ✓ Clean C(CP(=O)(CNC(=O)CN)O)C(=O)NCC(=O)O
CAC
2B0P
O33599 137.0 Da LogP -0.52 TPSA 40.1 ✓ Ro5 ✓ Clean C[As](=O)(C)[O-]
TLA
2B13
O33599 150.1 Da LogP -2.12 TPSA 115.1 ✓ Ro5 ✓ Clean [C@@H]([C@H](C(=O)O)O)(C(=O)O)O

PDB and ChEMBL records on this protein are shown in full. ChEMBL records from similar proteins are capped at the top 100 per protein (by pchembl) and ZINC at the top 50 (Tanimoto ≥ 0.5). ADME columns are descriptor-based screening flags, not experimental toxicity results.