Protein profile

KP13_00212

Protein-export protein secB

Genome: KpKP13

Gene: secB AHE42125.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3H025
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Amino acids 155
Annotations 5
Features 22
PDB binders 0
Druggability 0.834

Overview

Basic information about this protein and its source genome.

Accession
KP13_00212
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
secB AHE42125.1
Status
annotated
Amino acids
155
Structure source
AlphaFold + ColabFold
GO
GO:0015031 The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0051082 Binding to an unfolded protein. GO:0051262 The formation of a protein tetramer, a macromolecular structure consisting of four noncovalently associated identical or nonidentical subunits. GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0006457 The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
93.548
DEG E-value
1.94e-109
Localization
Cytoplasmic
ColabFold pLDDT
90.97

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.834
Structure A0A0H3H025
Pocket Pocket 2
P2Rank 0.152
Structure A0A0H3H025
Pocket Pocket 1
ColabFold model
FPocket 0.923 · Pocket 1
P2Rank 0.117 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 169 / 4744 genomes with a hit
Normalized 0.036

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

5 GO

Gene Ontology (GO)

5
  • GO:0015031 The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
  • GO:0051082 Binding to an unfolded protein.
  • GO:0051262 The formation of a protein tetramer, a macromolecular structure consisting of four noncovalently associated identical or nonidentical subunits.
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0006457 The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.

Sequence Features

Domain/signature hits from InterPro and related databases.

22 records
Show feature table
Start End DB Term Name
1 155 FunFam G3DSA:3.10.420.10:FF:000001 Protein-export chaperone SecB
13 30 PRINTS PR01594 Bacterial protein-transport SecB chaperone protein signature
13 30 InterPro IPR003708 Bacterial protein export chaperone SecB
97 119 PRINTS PR01594 Bacterial protein-transport SecB chaperone protein signature
97 119 InterPro IPR003708 Bacterial protein export chaperone SecB
73 93 PRINTS PR01594 Bacterial protein-transport SecB chaperone protein signature
73 93 InterPro IPR003708 Bacterial protein export chaperone SecB
123 141 PRINTS PR01594 Bacterial protein-transport SecB chaperone protein signature
123 141 InterPro IPR003708 Bacterial protein export chaperone SecB
1 145 Hamap MF_00821 Protein-export protein SecB [secB].
1 145 InterPro IPR003708 Bacterial protein export chaperone SecB
6 147 NCBIfam TIGR00809 protein-export chaperone SecB
6 147 InterPro IPR003708 Bacterial protein export chaperone SecB
11 139 CDD cd00557 Translocase_SecB
1 154 PANTHER PTHR36918 -
1 154 InterPro IPR003708 Bacterial protein export chaperone SecB
1 155 Gene3D G3DSA:3.10.420.10 -
1 155 InterPro IPR035958 SecB-like superfamily
3 141 SUPERFAMILY SSF54611 SecB-like
3 141 InterPro IPR035958 SecB-like superfamily
5 144 Pfam PF02556 Preprotein translocase subunit SecB
5 144 InterPro IPR003708 Bacterial protein export chaperone SecB

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3H025
AlphaFold — — full sequence — Viewing
ColabFold KP13_00212
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
2 0.834
3 0.453

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 3.05 0.101