Protein profile

KP13_00217

Putative L-lactate dehydrogenase operon regulatory protein

Genome: KpKP13

Gene: lldR AHE42130.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3H022
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Amino acids 254
Annotations 3
Features 25
PDB binders 0
Druggability 0.138

Overview

Basic information about this protein and its source genome.

Accession
KP13_00217
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
lldR AHE42130.1
Status
annotated
Amino acids
254
Structure source
AlphaFold + ColabFold
GO
GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
Cytoplasmic
ColabFold pLDDT
86.9

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.138
Structure A0A0H3H022
Pocket Pocket 20
P2Rank 0.169
Structure A0A0H3H022
Pocket Pocket 1
ColabFold model
FPocket 0.571 · Pocket 2
P2Rank 0.209 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 79 / 4744 genomes with a hit
Normalized 0.017

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

3 GO

Gene Ontology (GO)

3
  • GO:0006355 Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
  • GO:0003700 A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
  • GO:0003677 Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).

Sequence Features

Domain/signature hits from InterPro and related databases.

25 records
Show feature table
Start End DB Term Name
3 71 ProSiteProfiles PS50949 GntR-type HTH domain profile.
3 71 InterPro IPR000524 Transcription regulator HTH, GntR
2 236 PANTHER PTHR43537 TRANSCRIPTIONAL REGULATOR, GNTR FAMILY
97 219 Pfam PF07729 FCD domain
97 219 InterPro IPR011711 GntR, C-terminal
2 74 Gene3D G3DSA:1.10.10.10 -
2 74 InterPro IPR036388 Winged helix-like DNA-binding domain superfamily
97 221 SMART SM00895 FCD_2
97 221 InterPro IPR011711 GntR, C-terminal
4 72 SUPERFAMILY SSF46785 Winged helix DNA-binding domain
4 72 InterPro IPR036390 Winged helix DNA-binding domain superfamily
5 69 CDD cd07377 WHTH_GntR
5 69 InterPro IPR000524 Transcription regulator HTH, GntR
95 228 Gene3D G3DSA:1.20.120.530 -
95 228 InterPro IPR008920 Transcription regulator FadR/GntR, C-terminal
28 42 PRINTS PR00035 GntR bacterial regulatory protein HTH signature
28 42 InterPro IPR000524 Transcription regulator HTH, GntR
42 58 PRINTS PR00035 GntR bacterial regulatory protein HTH signature
42 58 InterPro IPR000524 Transcription regulator HTH, GntR
9 68 SMART SM00345 gntr3
9 68 InterPro IPR000524 Transcription regulator HTH, GntR
95 227 SUPERFAMILY SSF48008 GntR ligand-binding domain-like
95 227 InterPro IPR008920 Transcription regulator FadR/GntR, C-terminal
6 68 Pfam PF00392 Bacterial regulatory proteins, gntR family
6 68 InterPro IPR000524 Transcription regulator HTH, GntR

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3H022
AlphaFold — — full sequence — Viewing
ColabFold KP13_00217
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 2.81 0.087