Protein profile

KP13_00225

Inner membrane protein

Genome: KpKP13

Gene: AHE42139.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3GX95
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Amino acids 378
Annotations 2
Features 18
PDB binders 0
Druggability 0.808

Overview

Basic information about this protein and its source genome.

Accession
KP13_00225
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
AHE42139.1
Status
annotated
Amino acids
378
Structure source
AlphaFold + ColabFold
GO
GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
N
DEG identity (%)
0.0
Localization
CytoplasmicMembrane
ColabFold pLDDT
90.58

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.808
Structure A0A0H3GX95
Pocket Pocket 28
P2Rank 0.03
Structure A0A0H3GX95
Pocket Pocket 1
ColabFold model
FPocket 0.806 · Pocket 11
P2Rank 0.01 · Pocket 1
Core conservation Accessory gene
Roary accessory
CoreCruncher accessory
Gut microbiome 47 / 4744 genomes with a hit
Normalized 0.01

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

2 GO

Gene Ontology (GO)

2
  • GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
  • GO:0055085 The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

Sequence Features

Domain/signature hits from InterPro and related databases.

18 records
Show feature table
Start End DB Term Name
97 218 Gene3D G3DSA:1.10.287.470 Helix hairpin bin
1 15 Phobius SIGNAL_PEPTIDE Signal peptide region
117 137 Coils Coil Coil
1 2 Phobius SIGNAL_PEPTIDE_N_REGION N-terminal region of a signal peptide.
64 110 Pfam PF13533 Biotin-lipoyl like
64 110 InterPro IPR039562 Membrane fusion protein, biotin-lipoyl like domain
4 20 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
196 223 Coils Coil Coil
237 357 FunFam G3DSA:2.40.30.170:FF:000004 Auxiliary transport protein, membrane fusion protein family
3 10 Phobius SIGNAL_PEPTIDE_H_REGION Hydrophobic region of a signal peptide.
50 378 Phobius CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the cytoplasm.
62 249 Gene3D G3DSA:2.40.50.100 -
27 49 TMHMM TMhelix Region of a membrane-bound protein predicted to be embedded in the membrane.
60 281 SUPERFAMILY SSF111369 HlyD-like secretion proteins
35 372 PANTHER PTHR30386 MEMBRANE FUSION SUBUNIT OF EMRAB-TOLC MULTIDRUG EFFLUX PUMP
11 15 Phobius SIGNAL_PEPTIDE_C_REGION C-terminal region of a signal peptide.
16 30 Phobius NON_CYTOPLASMIC_DOMAIN Region of a membrane-bound protein predicted to be outside the membrane, in the extracellular region.
31 49 Phobius TRANSMEMBRANE Region of a membrane-bound protein predicted to be embedded in the membrane.

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3GX95
AlphaFold — — full sequence — Viewing
ColabFold KP13_00225
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
28 0.808
21 0.41
2 0.231

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 1.7 0.03
2 1.44 0.019