Protein profile

KP13_00240

Xylose isomerase

Genome: KpKP13

Gene: xylA AHE42152.1 Structure source: AlphaFold + ColabFold UniProt A0A0H3H006
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Amino acids 444
Annotations 6
Features 31
PDB binders 0
Druggability 0.452

Overview

Basic information about this protein and its source genome.

Accession
KP13_00240
Assembly
Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence
Gene
xylA AHE42152.1
Status
annotated
Amino acids
444
Structure source
AlphaFold + ColabFold
EC
5.3.1.5
GO
GO:0005975 The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0009045 Catalysis of the reaction: alpha-D-xylose = alpha-D-xylulofuranose. GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0000287 Binding to a magnesium (Mg) ion. GO:0042732 The chemical reactions and pathways involving D-xylose, a naturally occurring plant polysaccharide.

Target profile

Computed evidence for target prioritization.

Human off-target
No hit
Human identity (%)
0.0
Gut microbiome off-target
hit
Essential (DEG)
Y
DEG identity (%)
67.431
DEG E-value
0.0
Localization
Cytoplasmic
ColabFold pLDDT
97.27

Selected Druggability evidence

AlphaFold / UniProt model

Selected Druggability is the FPocket score chosen for ranking using the curated structure priority. The 3D viewer may show a different loaded structure, so its visible pockets can differ.

FPocket 0.452
Structure A0A0H3H006
Pocket Pocket 14
P2Rank 0.931
Structure A0A0H3H006
Pocket Pocket 1
ColabFold model
FPocket 0.587 · Pocket 2
P2Rank 0.926 · Pocket 1
Core conservation Conserved core gene
Roary core
CoreCruncher core
Gut microbiome 202 / 4744 genomes with a hit
Normalized 0.043

Sequence

Primary amino-acid sequence viewer.

Functional Annotations

Enzyme classification and Gene Ontology terms linked to this protein.

1 EC 5 GO

Enzyme Commission (EC)

1

Gene Ontology (GO)

5
  • GO:0005975 The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
  • GO:0009045 Catalysis of the reaction: alpha-D-xylose = alpha-D-xylulofuranose.
  • GO:0005737 The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
  • GO:0000287 Binding to a magnesium (Mg) ion.
  • GO:0042732 The chemical reactions and pathways involving D-xylose, a naturally occurring plant polysaccharide.

Sequence Features

Domain/signature hits from InterPro and related databases.

31 records
Show feature table
Start End DB Term Name
15 441 Hamap MF_00455 Xylose isomerase [xylA].
15 441 InterPro IPR001998 Xylose isomerase
39 441 ProSiteProfiles PS51415 Xylose isomerase family profile.
39 441 InterPro IPR001998 Xylose isomerase
7 444 Gene3D G3DSA:3.20.20.150 -
6 443 FunFam G3DSA:3.20.20.150:FF:000002 Xylose isomerase
8 441 NCBIfam TIGR02630 xylose isomerase
8 441 InterPro IPR013452 Xylose isomerase, bacterial-type
8 442 SUPERFAMILY SSF51658 Xylose isomerase-like
8 442 InterPro IPR036237 Xylose isomerase-like superfamily
116 136 Coils Coil Coil
160 179 PRINTS PR00688 Xylose isomerase signature
160 179 InterPro IPR001998 Xylose isomerase
275 302 PRINTS PR00688 Xylose isomerase signature
275 302 InterPro IPR001998 Xylose isomerase
304 315 PRINTS PR00688 Xylose isomerase signature
304 315 InterPro IPR001998 Xylose isomerase
337 348 PRINTS PR00688 Xylose isomerase signature
337 348 InterPro IPR001998 Xylose isomerase
184 205 PRINTS PR00688 Xylose isomerase signature
184 205 InterPro IPR001998 Xylose isomerase
96 118 PRINTS PR00688 Xylose isomerase signature
96 118 InterPro IPR001998 Xylose isomerase
137 157 PRINTS PR00688 Xylose isomerase signature
137 157 InterPro IPR001998 Xylose isomerase
211 230 PRINTS PR00688 Xylose isomerase signature
211 230 InterPro IPR001998 Xylose isomerase
233 257 PRINTS PR00688 Xylose isomerase signature
233 257 InterPro IPR001998 Xylose isomerase
6 440 PANTHER PTHR48306 XYLOSE ISOMERASE
6 440 InterPro IPR013452 Xylose isomerase, bacterial-type

3D Structure

Selected loaded structure. Experimental PDB entries may cover only a portion of the sequence; predicted models typically cover the full protein.

3D visualization script Full viewer

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Structural evidence

0 + 2

Experimental PDB entries and predicted models. Click Switch to display a different structure in the viewer.

Entry Method Resolution Chain Coverage Links Status
AlphaFold AF_A0A0H3H006
AlphaFold — — full sequence — Viewing
ColabFold KP13_00240
ColabFold — — full sequence — Loaded
Pocket details FPocket · P2Rank — toggle visibility and zoom from here, or open full viewer

Pockets (FPOCKET)

Showing top-ranked FPocket candidates by druggability. Druggability is color-coded: high (0.7 or higher), medium (0.4 to 0.69), low (below 0.4).

FPOCKET Sticks Spheres Surfaces Druggability Labels Zoom Positions
14 0.452
31 0.342

Pockets (P2RANK)

Showing top-ranked P2Rank candidates by probability. Probability is color-coded per P2Rank calibration: high (≥ 0.5), medium (0.2 – 0.49), low (< 0.2).

P2RANK Sticks Spheres Surfaces Score Probability Labels Zoom Positions
1 25.01 0.903
2 3.94 0.156
3 2.08 0.047
4 1.48 0.021